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Long\u2010term exposure to humans or animals can cause serious damage to the respiratory system. Melatonin is an endogenous natural hormone synthesized and released by the pineal gland. In this study, we investigated the effects of melatonin on in vitro cultured B[ghi]P\u2010exposed mouse oocytes and the protective roles of melatonin. Our data indicate that B[ghi]P exposure leads to meiotic maturation arrest and reduced ability of sperm binding and parthenogenetic activation. Also, B[ghi]P exposure disrupts actin filament dynamics, spindle assembly, and kinetochore\u2013microtubule attachment stability, which results in oocyte aneuploidy. Simultaneously, B[ghi]P exposure disturbs the distribution of mitochondria, increases the level of oxidative stress, and induces apoptosis of oocytes. Whereas all of these toxic effects of B[ghi]P can be restored after melatonin supplement. In conclusion, our findings validate that melatonin has a certain protective effect on preventing the reduced oocyte quality caused by B[ghi]P exposure during meiotic maturation in mouse oocytes.<\/jats:p>","DOI":"10.1002\/jcp.27351","type":"journal-article","created":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T07:01:41Z","timestamp":1539500501000},"page":"6220-6229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Melatonin defends mouse oocyte quality from benzo[ghi]perylene\u2010induced deterioration"],"prefix":"10.1002","volume":"234","author":[{"given":"Wei\u2010Dong","family":"Li","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology College of Life Sciences, Institute of Reproductive Sciences, Qingdao Agricultural University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology College of Life Sciences, Institute of Reproductive Sciences, Qingdao Agricultural University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Ming","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology College of Life Sciences, Institute of Reproductive Sciences, Qingdao Agricultural University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology College of Life Sciences, Institute of Reproductive Sciences, Qingdao Agricultural University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-7885","authenticated-orcid":false,"given":"Shen","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology College of Life Sciences, Institute of Reproductive Sciences, Qingdao Agricultural University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Yuan","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology College of Life Sciences, Institute of Reproductive Sciences, Qingdao Agricultural University Qingdao China"},{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,14]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atmosres.2012.10.003"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.12.002"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18595"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2005.00282.x"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2000.9082"},{"issue":"3","key":"e_1_2_7_1_7_1","first-page":"539","article-title":"Experimental studies in rat lungs on the carcinogenicity and dose\u2010response relationships of eight frequently occurring environmental polycyclic aromatic hydrocarbons","volume":"71","author":"Deutsch\u2010Wenzel R. 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