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Due to altered sex steroid receptor concentrations and other signaling defects, eutopic endometriotic tissues have an attenuated response to progesterone. This progesterone\u2010resistance contributes to lesion survival, proliferation, pain, and infertility. The current agency\u2010approved hormonal therapies, including synthetic progestins, GnRH agonists, and danazol are often of limited efficacy and counterproductive to fertility and cause systemic side effects due to suppression of endogenous steroid hormone levels. In the current study, we examined the effects of curcumin (CUR, diferuloylmethane), which has long been used as an anti\u2010inflammatory folk medicine in Asian countries for this condition. The basal levels of proinflammatory and proangiogenic chemokines and cytokines expression were higher in primary cultures of stromal cells derived from eutopic endometrium of endometriosis (EESC) subjects compared with normal endometrial stromal cells (NESC). The treatment of EESC and NESC with CUR significantly and dose\u2010dependently reduced chemokine and cytokine secretion over the time course. Notably, CUR treatment significantly decreased phosphorylation of the IKK\u03b1\/\u03b2, NF\u2010\u03baB, STAT3, and JNK signaling pathways under these experimental conditions. Taken together, our findings suggest that CUR has therapeutic potential to abrogate aberrant activation of chemokines and cytokines, and IKK\u03b1\/\u03b2, NF\u2010\u03baB, STAT3, and JNK signaling pathways to reduce inflammation associated with endometriosis.<\/jats:p>","DOI":"10.1002\/jcp.27360","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T06:07:56Z","timestamp":1538028476000},"page":"6298-6312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF\u2010\u03baB signaling pathway"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9748-6574","authenticated-orcid":false,"given":"Indrajit","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Morehouse School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saswati","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Morehouse School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Driss","sequence":"additional","affiliation":[{"name":"Department of Physiology Morehouse School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Physiology Morehouse School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherifeh","family":"Mehrabi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Morehouse School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceana","family":"Nezhat","sequence":"additional","affiliation":[{"name":"Nezhat Medical Center Atlanta Center for Minimally Invasive Surgery and Reproductive Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Sidell","sequence":"additional","affiliation":[{"name":"Department of Gynecology &amp; Obstetrics Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winston E.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Morehouse School of Medicine Atlanta Georgia"},{"name":"Department of Physiology Morehouse School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/S0962935196000567"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/228402651000200102"},{"key":"e_1_2_8_1_4_1","first-page":"5","article-title":"Pharmacological and clinical properties of curcumin","volume":"1","author":"Beevers C. 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