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Melatonin an indoleamine produced in the pineal gland mediated and receptor\u2010independent action is the pancreas and other where has both receptors. Melatonin is a potent antioxidant and tissue protector against inflammation and oxidative stress. In vivo and in vitro studies have shown that melatonin supplementation is an appropriate therapeutic approach for pancreatic cancer. Melatonin may be an effective apoptosis inducer in cancer cells through regulation of a large number of molecular pathways including oxidative stress, heat shock proteins, and vascular endothelial growth factor. Limited clinical studies, however, have evaluated the role of melatonin in pancreatic cancer. This review summarizes what is known regarding the effects of melatonin on pancreatic cancer and the mechanisms involved.<\/jats:p>","DOI":"10.1002\/jcp.27372","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T11:44:30Z","timestamp":1537357470000},"page":"5372-5378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Melatonin and pancreatic cancer: Current knowledge and future perspectives"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2492-3996","authenticated-orcid":false,"given":"Omid Reza","family":"Tamtaji","sequence":"first","affiliation":[{"name":"Physiology Research Center, Kashan University of Medical Sciences Kashan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naghmeh","family":"Mirhosseini","sequence":"additional","affiliation":[{"name":"Pure North S\u2019Energy Foundation Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russel J.","family":"Reiter","sequence":"additional","affiliation":[{"name":"Department of Cellular and Structural Biology University of Texas Health Science, Center San Antonio Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morteza","family":"Behnamfar","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences Bojnurd Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5265-4792","authenticated-orcid":false,"given":"Zatollah","family":"Asemi","sequence":"additional","affiliation":[{"name":"Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences Kashan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"e_1_2_5_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010014\u20101579\u20102"},{"key":"e_1_2_5_1_3_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC402_7"},{"key":"e_1_2_5_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12135"},{"key":"e_1_2_5_1_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01284"},{"key":"e_1_2_5_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/35019501"},{"key":"e_1_2_5_1_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.30868"},{"key":"e_1_2_5_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/35023595"},{"key":"e_1_2_5_1_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000179137"},{"key":"e_1_2_5_1_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020107915919"},{"key":"e_1_2_5_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200301000-00010"},{"key":"e_1_2_5_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010079X.2012.01009.x"},{"key":"e_1_2_5_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010079X.2010.00848.x"},{"key":"e_1_2_5_1_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.00989.x"},{"key":"e_1_2_5_1_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-89-1-301"},{"key":"e_1_2_5_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/35065000"},{"key":"e_1_2_5_1_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3182374ace"},{"key":"e_1_2_5_1_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015910792246155"},{"key":"e_1_2_5_1_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000128681.76786.07"},{"key":"e_1_2_5_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4644(20010101)80:1<53::AID-JCB60>3.0.CO;2-E"},{"key":"e_1_2_5_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010079X.2010.00834.x"},{"key":"e_1_2_5_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208513"},{"issue":"2","key":"e_1_2_5_1_23_1","first-page":"547","article-title":"Differential expression of heat shock proteins in pancreatic carcinoma","volume":"54","author":"Gress T. 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