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However, the specific diagnostic biomarkers have not been fully clarified and candidate regulatory targets for IPAH have not been identified. The aim of this study was to explore the potential diagnostic biomarkers and possible regulatory targets of IPAH. We performed a weighted gene coexpression network analysis and calculated module\u2010trait correlations based on a public microarray data set (GSE703) and six modules were found to be related to IPAH. Two modules which have the strongest correlation with IPAH were further analyzed and the top 10 hub genes in the two modules were identified. Furthermore, we validated the data by quantitative real\u2010time polymerase chain reaction (qRT\u2010PCR) in an independent sample set originated from our study center. Overall, the qRT\u2010PCR results were consistent with most of the results of the microarray analysis. Intriguingly, the highest change was found for <jats:italic>YWHAB<\/jats:italic>, a gene encodes a protein belonging to the 14\u20103\u20103 family of proteins, members of which mediate signal transduction by binding to phosphoserine\u2010containing proteins. Thus, \n<jats:italic>YWHAB<\/jats:italic> was subsequently selected for validation. In congruent with the gene expression analysis, plasma 14\u20103\u20103\u03b2 concentrations were significantly increased in patients with IPAH compared with healthy controls, and 14\u20103\u20103\u03b2 expression was also positively correlated with mean pulmonary artery pressure (\n<jats:italic>R<\/jats:italic>\n<jats:sup>2<\/jats:sup>\u2009=\u20090.8783; \n<jats:italic>p\u2009&lt;\u2009<\/jats:italic>0.001). Taken together, using weighted gene coexpression analysis, \n<jats:italic>YWHAB<\/jats:italic> was identified and validated in association with IPAH progression, which might serve as a biomarker and\/or therapeutic target for IPAH.<\/jats:p>","DOI":"10.1002\/jcp.27381","type":"journal-article","created":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T11:15:37Z","timestamp":1539515737000},"page":"6449-6462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Integrated bioinformatic analysis reveals <i>YWHAB<\/i> as a novel diagnostic biomarker for idiopathic pulmonary arterial hypertension"],"prefix":"10.1002","volume":"234","author":[{"given":"Tao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Division of Cardiology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology Wuhan China"},{"name":"Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cardiology, Wuhan Asia Heart Hospital, Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruidong","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate Program in Genetics, Genomics, and Bioinformatics, University of California Riverside California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wuhan Asia Heart Hospital, Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Cardiology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology Wuhan China"},{"name":"Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Cardiology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology Wuhan China"},{"name":"Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Cardiology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology Wuhan China"},{"name":"Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan 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Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology Wuhan China"},{"name":"Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Cardiology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology Wuhan China"},{"name":"Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9338-5808","authenticated-orcid":false,"given":"Hesong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Cardiology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology Wuhan China"},{"name":"Hubei Key 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