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However, little is known about snake\u2010venom\u2010mediated effects when used at low, noncytotoxic concentrations. In the current study, two human fibroblast cell lines of different origin, namely WI\u201038 fetal lung fibroblasts and BJ foreskin fibroblasts were used to investigate snake\u2010venom\u2010induced adaptive response at a relatively noncytotoxic concentration (0.01\u2009\u00b5g\/ml). The venoms of Indochinese spitting cobra (\n<jats:italic>Naja siamensis<\/jats:italic>), western green mamba (\n<jats:italic>Dendroaspis viridis<\/jats:italic>), forest cobra (\n<jats:italic>Naja melanoleuca<\/jats:italic>), and southern copperhead (\n<jats:italic>Agkistrodon contortrix<\/jats:italic>) were considered. Snake venoms promoted FOXO3a\u2010mediated oxidative stress response and to a lesser extent DNA damage response, which lead to changes in cell cycle regulators both at messenger RNA and protein levels, limited cell proliferation and migration, and induced cellular senescence. Taken together, we have shown for the first time that selected snake venoms may also exert adverse effects when used at relatively noncytotoxic concentrations.<\/jats:p>","DOI":"10.1002\/jcp.27382","type":"journal-article","created":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T11:20:07Z","timestamp":1539516007000},"page":"6147-6160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Snake venoms promote stress\u2010induced senescence in human fibroblasts"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8055-1918","authenticated-orcid":false,"given":"Anna","family":"Lewinska","sequence":"first","affiliation":[{"name":"Department of Cell Biochemistry Faculty of Biotechnology, University of Rzeszow Rzeszow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Bocian","sequence":"additional","affiliation":[{"name":"Department of 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