{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:47:04Z","timestamp":1785887224849,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["No. F 14\u20102\/2008(NS\/PE)"],"award-info":[{"award-number":["No. F 14\u20102\/2008(NS\/PE)"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The activation of two transcription factors, NF\u03baB and NICD (notch intracellular domain), plays a crucial role in different stages of atherosclerotic disease progression, from early endothelial activation by modified lipids like oxidized low\u2010density lipoprotein (oxyLDL) to the imminent rupture of the atherosclerotic plaque. Inflammatory mediators and the notch pathway proteins were upregulated in atherogenic diet\u2010induced rats and the same was confirmed by the differentiation of monocyte to macrophage on exposure to oxyLDL. The inflammatory transcription factor NF\u03baB and the notch signaling transcription factor NICD were analysed for their molecular interaction in monocyte to macrophage differentiation. Inhibition of NF\u03baB by dexamethasone in monocyte to macrophage differentiation resulted in a concomitant downregulation of NICD, whereas inhibition of NICD by N\u2010(N\u2010[3, 5\u2010difluorophenacetyl])\u2010l\u2010alanyl)\u2010S\u2010phenylglycine t\u2010butyl ester (DAPT), a \u03b3\u2013secretase inhibitor, did not significantly influence the expression of NF\u03baB, but downregulated macrophage differentiation. These findings revealed that NF\u03baB inhibition using dexamethasone regulated NICD, which turned down macrophage differentiation. Thus, inhibition of both NF\u03baB\u2013NICD is a potential target for intervention in atherosclerosis.<\/jats:p>","DOI":"10.1002\/jcp.27458","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T09:11:49Z","timestamp":1543309909000},"page":"7040-7050","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Molecular interaction of NF\u03baB and NICD in monocyte\u2013macrophage differentiation is a target for intervention in atherosclerosis"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7421-0754","authenticated-orcid":false,"given":"Ambika","family":"Binesh","sequence":"first","affiliation":[{"name":"Department of Zoology Unit of Biochemistry, University of Madras, Guindy Campus Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivasithamparam 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