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A critical factor in the success of periodontal regeneration is the rapid resolution of inflammatory responses in the tissue. We explored an anti\u2010inflammatory effect of FGF\u20102 during periodontal regeneration and healing. We found that FGF\u20102 on mouse periodontal ligament cells (MPDL22) markedly downregulated CD40 expression, a key player of inflammation. In addition, FGF\u20102 inhibited CD40 signaling by the non\u2010canonical nuclear factor\u2010kappa B2 (NF\u03baB2) pathway, resulting in decreased production of interleukin\u20106 (IL\u20106) and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), which have the potential to recruit immune cells to inflamed sites. Furthermore, in vivo treatment of FGF\u20102 enhanced healing of skin wounds by counteracting the CD40\u2010mediated inflammation. 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