{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:52:44Z","timestamp":1775595164956,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T00:00:00Z","timestamp":1539475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neuropathic pain caused by somatosensory nervous system dysfunction is a serious public health problem. Some long noncoding RNAs (lncRNAs) can participate in physiological processes involved in neuropathic pain. However, the effects of lncRNA DGCR5 in neuropathic pain have not been explored. Therefore, in our current study, we concentrated on the biological roles of DGCR5 in neuropathic pain. Here, it was observed that DGCR5 was significantly decreased in chronic sciatic nerve injury (CCI) rat models. DGCR5 overexpression was able to alleviate neuropathic pain development including mechanical and thermal hyperalgesia. In addition, the current understanding of miR\u2010330\u20103p function in neuropathic pain remains largely incomplete. Here, we found that miR\u2010330\u20103p was greatly increased in CCI rats and DGCR5 can modulate miR\u2010330\u20103p expression negatively. Upregulation of DGCR5 repressed inflammation\u2010correlated biomarkers including interleukin 6 (IL\u20106), tumor necrosis factor \u03b1, and IL\u20101\u03b2 in CCI rats by sponging miR\u2010330\u20103p. The negative correlation between DGCR5 and miR\u2010330\u20103p was confirmed in our current study. Inhibition of miR\u2010330\u20103p suppressed neuropathic pain progression by restraining neuroinflammation in vivo. In addition, PDCD4 was predicted as a downstream target of miR\u2010330\u20103p. Furthermore, PDCD4 was significantly increased in CCI rats and DGCR5 regulated PDCD4 expression through sponging miR\u2010330\u20103p in CCI rat models. Taken these together, it was implied that DGCR5\/miR\u2010330\u20103p\/PDCD4 axis participated in neuropathic pain treatment.<\/jats:p>","DOI":"10.1002\/jcp.27487","type":"journal-article","created":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T10:40:36Z","timestamp":1539513636000},"page":"7292-7300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["DGCR5 attenuates neuropathic pain through sponging miR\u2010330\u20103p and regulating PDCD4 in CCI rat models"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9890-4926","authenticated-orcid":false,"given":"Chengwei","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Tongji Hospital affiliated Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Gongli Hospital, The Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Tongren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Tongren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,14]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25939"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.02.012"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.573089"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.08.013"},{"issue":"7","key":"e_1_2_6_1_7_1","first-page":"1463","article-title":"Long non\u2010coding RNA DGCR5 is involved in the regulation of proliferation, migration and invasion of lung cancer by targeting miR\u20101180","volume":"7","author":"Chen E. 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