{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:25:21Z","timestamp":1778538321298,"version":"3.51.4"},"reference-count":82,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective and Background<\/jats:title><jats:p>Chronic myeloid leukemia (CML) is a neoplastic disease whose genetic and cytogenetic changes play important roles in prognosis and treatment strategies. Philadelphia (Ph) translocation t(9;22)(q34;q11) is a diagnostic and prognostic biomarker in CML.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pubmed and Google Scholar databases were searched for English language articles from 1975 to 2017 containing the terms CML; Additional chromosomal abnormalities; Philadelphia translocation; Prognosis; and Treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Approximately 10\u201312% of CML patients exhibit additional chromosomal aberrations (ACAs) in chronic phase and blast crisis. ACAs emergence may cause different features in CML patients according to Ph pattern. For instance, deletion of chromosome 9 derivation is associated to patient\u2019s bad survival, whereas monosomy 7 develops myeloid dysplastic syndrome (MDS) or acute myeloid leukemia (AML) in CML patients with Ph\u2010negative pattern. And ACAs in Ph\u2010positive CML is considered as a failure in the management of CML with imatinib.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CML classification using different features such as Ph and ACAs can play a decisive role in the evaluation of treatment responses in patients, for example, CML patients with Ph negative and monosomy 7 develop MDS or CML patient \u2013Y and extra copy of Ph have a good response to tyrosine kinase inhibitors, therefore, classifications according to Ph and ACAs play an important role in choosing better treatment protocols and therapeutic strategies. Karyotype analysis in CML patients with complex karyotype shows unrandom pattern so ACAs can be great clue in medical guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.27505","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T08:07:38Z","timestamp":1542269258000},"page":"5798-5806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Chronic myeloid leukemia with complex karyotypes: Prognosis and therapeutic approaches"],"prefix":"10.1002","volume":"234","author":[{"given":"Ali Amin","family":"Asnafi","sequence":"first","affiliation":[{"name":"Research Center of Thalassemia &amp; Hemoglobinopathy Health Research Institute, Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8621-5904","authenticated-orcid":false,"given":"Zeinab","family":"Deris Zayeri","sequence":"additional","affiliation":[{"name":"Golestan Hospital Clinical Research Development Unit Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeid","family":"Shahrabi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Hematology, Faculty of Medicine Semnan University of Medical Sciences Semnan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazem","family":"Zibara","sequence":"additional","affiliation":[{"name":"ER045, Laboratory of Stem Cells, DSST, Biology Department, Faculty of Sciences Lebanese University Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Vosughi","sequence":"additional","affiliation":[{"name":"Research Center of Thalassemia &amp; Hemoglobinopathy Health Research Institute, Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,14]]},"reference":[{"key":"e_1_2_11_1_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol_00000139"},{"key":"e_1_2_11_1_3_1","doi-asserted-by":"publisher","DOI":"10.4236\/jct.2016.74030"},{"key":"e_1_2_11_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62120-0"},{"key":"e_1_2_11_1_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2017.967"},{"key":"e_1_2_11_1_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.0779"},{"key":"e_1_2_11_1_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-501569"},{"key":"e_1_2_11_1_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35660"},{"key":"e_1_2_11_1_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5359.125881"},{"key":"e_1_2_11_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-015-0248-2"},{"key":"e_1_2_11_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90121-5"},{"key":"e_1_2_11_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-012-0443-1"},{"key":"e_1_2_11_1_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.615425"},{"key":"e_1_2_11_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.231"},{"key":"e_1_2_11_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90351-8"},{"key":"e_1_2_11_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950115)75:2<464::AID-CNCR2820750209>3.0.CO;2-E"},{"issue":"4","key":"e_1_2_11_1_17_1","first-page":"502","article-title":"The impact of additional cytogenetic abnormalities at diagnosis and during therapy with tyrosine kinase inhibitors in chronic myeloid leukaemia","volume":"8","author":"Crisan A. 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