{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:38:34Z","timestamp":1791221914208,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T00:00:00Z","timestamp":1539475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["214S567"],"award-info":[{"award-number":["214S567"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Irisin is a product of fibronectin type III domain\u2010containing protein 5 (FNDC5) and plays an important role in energy homeostasis. In this study, we aimed to determine effects of intracerebroventricular administration of irisin on the hypothalamus\u2013pituitary\u2013gonadal axis by molecular, biochemical, and morphological findings.<\/jats:p><jats:p>Fourty male Wistar\u2010Albino rats were used and divided into four groups including control, sham (vehicle), 10, and 100\u2009nM irisin infused groups (<jats:italic>n<\/jats:italic>\u2009=\u200910). Hypothalamic gonadotropin releasing hormone (GnRH) level and serum luteinizing hormone (LH), follicle\u2010stimulating hormone (FSH), and testosterone levels were determined. Testicular tissue histology and spermiogram analysis were also performed.<\/jats:p><jats:p>Both irisin concentrations significantly reduced hypothalamic GnRH messenger RNA (mRNA) and protein levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). It was found that serum LH, FSH, and testosterone levels and Sertoli and Leydig cell numbers were decreased by irisin administration (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In addition, irisin administration reduced sperm density and mobility (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). However, it did not cause any change in testicular and epididymis weights and tubular diameter.<\/jats:p><jats:p>Our results reveal that irisin can play a role in the central regulation of reproductive behavior and also reduces testosterone levels by suppressing LH and FSH secretion. These results suggest that the discovery of irisin receptor antagonists may be beneficial in the treatment of infertility.<\/jats:p>","DOI":"10.1002\/jcp.27541","type":"journal-article","created":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T10:44:55Z","timestamp":1539513895000},"page":"8815-8824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Effects of intracerebroventricular administration of irisin on the hypothalamus\u2013pituitary\u2013gonadal axis in male rats"],"prefix":"10.1002","volume":"234","author":[{"given":"Suat","family":"Tekin","sequence":"first","affiliation":[{"name":"Department of Physiology Faculty of Medicine,\u00a0Inonu University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Beytur","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine, Inonu University Malatya 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