{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:13:32Z","timestamp":1791000812624,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extensive investigations into long noncoding RNAs (lncRNAs) in various diseases and cancers, including acute myocardial infarction (AMI) have been conducted. The current study aimed to investigate the role of lncRNA\u00a0solute carrier family 8 member A1 antisense RNA 1 (SLC8A1\u2010AS1) in myocardial damage by targeting solute carrier family 8 member A1 (SLC8A1) via cyclic guanosine 3\u2032,5\u2032\u2010monophosphate\u2010protein kinase G (cGMP\u2010PKG) signaling pathway in AMI mouse models. Differentially expressed lncRNA in AMI were initially screened and target relationship between lncRNA SLC8A1\u2010AS1 and SLC8A1 was then verified. Infarct size, levels of inflammatory factors, biochemical indicators, and the positive expression of the SLC8A1 protein in AMI were subsequently determined. The expression of SLC8A1\u2010AS1, SLC8A1, PKG1, PKG2, atrial natriuretic peptide, and brain natriuretic peptide was detected to assess the effect of SLC8A1\u2010AS1 on SLC8A1 and cGMP\u2010PKG. The respective contents of superoxide dismutase, lactate dehydrogenase (LDH), and malondialdehyde (MDA) were detected accordingly. Microarray data GSE66360 provided evidence indicating that SLC8A1\u2010AS1 was poorly expressed in AMI. SLC8A1 was verified to be a target gene of lncRNA SLC8A1\u2010AS1. SLC8A1\u2010AS1 upregulation decreased levels of left ventricular end\u2010systolic diameter, \u2212<jats:italic>dp<\/jats:italic>\/\n<jats:italic>dt<\/jats:italic>\n<jats:sub>max<\/jats:sub>, interleukin 1\u03b2 (IL\u20101\u03b2),\u00a0IL\u20106, transforming growth factor \u03b1, nitric oxide, inducible nitric\u2010oxide synthase, endothelial nitric\u2010oxide synthase, infarct size, LDH activity and MDA content, and increased IL\u201010, left ventricular end\u2010diastolic pressure\u00a0and +\n<jats:italic>dp<\/jats:italic>\/\n<jats:italic>dt<\/jats:italic>\n<jats:sub>max<\/jats:sub>. Furthermore, the overexpression of SLC8A1\u2010AS1 was noted to elicit an inhibitory effect on the cGMP\u2010PKG signaling pathway via SLC8A1. In conclusion, lncRNA SLC8A1\u2010AS1, by downregulating SLC8A1 and activating the cGMP\u2010PKG signaling pathway, was observed to alleviate myocardial damage, inhibit the release of proinflammatory factors and reduce infarct size, ultimately protecting against myocardial damage.<\/jats:p>","DOI":"10.1002\/jcp.27574","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T04:46:18Z","timestamp":1540961178000},"page":"9019-9032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["LncRNA SLC8A1\u2010AS1 protects against myocardial damage through activation of cGMP\u2010PKG signaling pathway by inhibiting SLC8A1 in mice models of myocardial infarction"],"prefix":"10.1002","volume":"234","author":[{"given":"Gong\u2010Liang","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Cardiology China\u2010Japan Union Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Qun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Hua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-756X","authenticated-orcid":false,"given":"Hai\u2010Ming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology China\u2010Japan Union Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00480-9"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-12-r139"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2010.08.009"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep00052"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2010.0036"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.12.017"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-34"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088566"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.12.007"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-029-8_18"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-469"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2016.01.004"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-010-0694-0"},{"key":"e_1_2_7_1_15_1","first-page":"206039","article-title":"Danger signals in the initiation of the inflammatory response after myocardial infarction","volume":"2013","author":"Haan J. J.","year":"2013","journal-title":"Mediators of Inflammation"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.06.007"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.02.013"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12959"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/83324"},{"key":"e_1_2_7_1_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.224915"},{"key":"e_1_2_7_1_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303915"},{"key":"e_1_2_7_1_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20101"},{"key":"e_1_2_7_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.08.005"},{"key":"e_1_2_7_1_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000478870"},{"key":"e_1_2_7_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2015.12.032"},{"key":"e_1_2_7_1_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-3930.60006"},{"key":"e_1_2_7_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.11.097"},{"key":"e_1_2_7_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.05.004"},{"key":"e_1_2_7_1_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/10430349950018012"},{"key":"e_1_2_7_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.09.037"},{"key":"e_1_2_7_1_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2711"},{"key":"e_1_2_7_1_32_1","doi-asserted-by":"publisher","DOI":"10.2202\/1544-6115.1027"},{"key":"e_1_2_7_1_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2008.00937.x"},{"key":"e_1_2_7_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.03.026"},{"key":"e_1_2_7_1_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm355"},{"key":"e_1_2_7_1_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1283220"},{"key":"e_1_2_7_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.11.146"},{"key":"e_1_2_7_1_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt439"},{"key":"e_1_2_7_1_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7779"},{"key":"e_1_2_7_1_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000119"},{"issue":"13","key":"e_1_2_7_1_41_1","first-page":"2819","article-title":"LncRNA UCA1 promotes epithelial\u2010mesenchymal transition (EMT) of breast cancer cells via enhancing Wnt\/beta\u2010catenin signaling pathway","volume":"20","author":"Xiao C.","year":"2016","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_7_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2014.05.011"},{"issue":"3","key":"e_1_2_7_1_43_1","first-page":"2582","article-title":"Cardiac hypertrophy is positively regulated by long non\u2010coding RNA PVT1","volume":"8","author":"Yu Y. H.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_7_1_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-0701-x"},{"key":"e_1_2_7_1_45_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16355"},{"key":"e_1_2_7_1_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10701"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.27574","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.27574","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.27574","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.27574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T20:27:32Z","timestamp":1692649652000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.27574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,30]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/jcp.27574"],"URL":"https:\/\/doi.org\/10.1002\/jcp.27574","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,30]]},"assertion":[{"value":"2018-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}