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Despite the unknown cause of BD, there is\u00a0some strong documentation\u00a0for immunological, genetic, environmental, and infectious factors playing a role in the pathogenesis of BD. While the nature of the genetic variants remains unidentified, many genetic risk factors are considered to contribute to BD susceptibility. Along with human leukocyte antigen gene encoding B*51 (HLA\u2010B*51) and areas including the major histocompatibility complex class I, genome\u2010wide association studies have recognized numerous other BD susceptibility genes including those encoding interleukin (IL)\u201010, IL\u201012 receptor \u03b2 2 (IL\u201012RB2), IL\u201023 receptor (IL\u201023R), C\u2010C chemokine receptor 1 gene, signal transducer and activator of transcription 4 (STAT4), endoplasmic reticulum aminopeptidase (ERAP1), and genes encoding killer cell lectin\u2010like receptor family members (KLRC4\u2010KLRK1). It is believed that BD could be considered as a disorder lying\u00a0in between autoimmune and autoinflammatory syndromes. The positive responses to classical immunosuppressive agents like azathioprine and cyclosporine\u00a0and involvement of autoantigens in the initiation of the disorder are the main BD features that reflect the autoimmune nature of the disorder. In this review, we address recent findings on the role of common cytokines, antibodies and immunogenetic factors in BD.<\/jats:p>","DOI":"10.1002\/jcp.27576","type":"journal-article","created":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T06:39:49Z","timestamp":1540017589000},"page":"8055-8074","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Beh\u00e7et\u2019s disease: An immunogenetic perspective"],"prefix":"10.1002","volume":"234","author":[{"given":"Arash","family":"Salmaninejad","sequence":"first","affiliation":[{"name":"Drug Applied Research Center, Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Department of Medical Genetics Medical Genetics Research Center, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad 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