{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:48:49Z","timestamp":1792529329263,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T00:00:00Z","timestamp":1539475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The molecular mechanism of liver fibrosis caused by hepatitis C virus (HCV) is not clear. The aim of this study is to understand the molecular mechanism of liver fibrosis induced by HCV and to identify potential therapeutic targets for hepatic fibrosis. We analyzed gene expression patterns between high liver fibrosis and low liver fibrosis samples, and identified genes related to liver fibrosis. We identified <jats:italic>TAF1<\/jats:italic>, <jats:italic>HNF4A<\/jats:italic>, and <jats:italic>CALM2<\/jats:italic> were related to the development of liver fibrosis. <jats:italic>HNF4A<\/jats:italic> is important for hepatic fibrogenesis, and upregulation of <jats:italic>HNF4A<\/jats:italic> is an ideal choice for treating liver fibrosis. The gene expression of <jats:italic>CALM2<\/jats:italic> is significantly lower in liver fibrosis samples than nonfibrotic samples. <jats:italic>TAF1<\/jats:italic> may serve as a biomarker for liver fibrosis. The results were further validated by an independent data set GSE84044. In summary, our study described changes in the gene expression during the occurrence and development of liver fibrosis. The <jats:italic>TAF1<\/jats:italic>, <jats:italic>HNF4A<\/jats:italic>, and <jats:italic>CALM2<\/jats:italic> may serve as novel targets for the treatment of liver fibrosis.<\/jats:p>","DOI":"10.1002\/jcp.27579","type":"journal-article","created":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T11:10:47Z","timestamp":1539515447000},"page":"9045-9051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Identification of <i>TAF1<\/i>, <i>HNF4A<\/i>, and <i>CALM2<\/i> as potential therapeutic target genes for liver fibrosis"],"prefix":"10.1002","volume":"234","author":[{"given":"Dong","family":"Ji","sequence":"first","affiliation":[{"name":"Liver Cirrhosis Treatment and Research Center II, 302 Military Hospital of China Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Liver Cirrhosis Treatment and Research 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