{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:20:23Z","timestamp":1789993223859,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,11,11]],"date-time":"2018-11-11T00:00:00Z","timestamp":1541894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the current study was to investigate the effects and the underlying mechanisms of troxerutin on myocardial cell apoptosis during ischemia\u2010reperfusion (I\/R) injury. Hypoxia\/reoxygenation (H\/R) model in neonatal rat cardiomyocytes, and I\/R model in rats, were established following troxerutin preconditioning. The quantitative real\u2010time polymerase chain reaction analysis was performed to examine the messenger RNA miR\u2010146a\u20105p expression in cardiomyocytes and myocardial tissues. Hemodynamic parameters and serum creatine kinase, lactate dehydrogenase, tumor necrosis factor\u2010\u03b1, and interleukin\u201010 were evaluated. Infarct size was examined by 2,3,5\u2010triphenyltetrazolium chloride staining. Besides, myocardial apoptosis was detected by terminal deoxynucleotidyl transferase (dUTP) nick end labeling (TUNEL) assay. Western blot analysis was performed to determine the protein levels of caspase\u20103, Bax, and Bcl\u20102. The results showed that, troxerutin decreased rat cardiomyocyte apoptosis during H\/R injury. Furthermore, the antiapoptotic effect of troxerutin against I\/R injury was mediated by miR\u2010146a\u20105p downregulation. In vivo experiments suggested that troxerutin alleviated myocardial I\/R injury in rats via inhibition of miR\u2010146a\u20105p. In conclusion, troxerutin exerted cardioprotective effects during I\/R injury by downregulating miR\u2010146a\u20105p.<\/jats:p>","DOI":"10.1002\/jcp.27607","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T06:09:27Z","timestamp":1542002967000},"page":"9274-9282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Troxerutin attenuates myocardial cell apoptosis following myocardial ischemia\u2010reperfusion injury through inhibition of miR\u2010146a\u20105p expression"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7232-5232","authenticated-orcid":false,"given":"Liliang","family":"Shu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanzhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Second Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongcheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,11]]},"reference":[{"key":"e_1_2_5_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2016.12.006"},{"key":"e_1_2_5_1_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144877"},{"key":"e_1_2_5_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12795"},{"key":"e_1_2_5_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.07.014"},{"key":"e_1_2_5_1_6_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X13500237"},{"key":"e_1_2_5_1_7_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2015.7.11089"},{"key":"e_1_2_5_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.02.010"},{"key":"e_1_2_5_1_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0672-0"},{"issue":"3","key":"e_1_2_5_1_10_1","first-page":"334","article-title":"Protective effect of Crocus sativus L. 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