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However, due to its insignificant intestinal\u2010liver metabolism, low stability, quick systemic elimination and its hydrophobic property with low solubility, curcumin has limited bioavailability. Exosomes are nanovesicles (30\u2013100\u2009nm) released from diverse cell types into extracellular and, ultimately, into bio\u2010fluids in a tightly regulated manner. Exosomes are capable of transferring lipids, proteins, RNAs and DNAs, both with and without direct cell\u2010to\u2010cell contact. Curcumin\u2010encapsulated exosomes are highly bioavailable, soluble and safe, and can reach high concentrations in the blood; they, therefore, have therapeutic potential without toxic effects and immune stimulation. Thus, curcumin\u2010encapsulated exosomes could be superior to other synthetic nanoparticles as a carrier of curcumin. The aim of the current review is to offer an overview of the in vitro, in vivo and clinical studies pertaining to the role of curcumin\u2010primed and curcumin\u2010encapsulated exosomes in the treatment of cancer, oxidative stress, brain disorders, cholesterol, and endothelial dysfunction.<\/jats:p>","DOI":"10.1002\/jcp.27615","type":"journal-article","created":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T06:31:00Z","timestamp":1539498660000},"page":"8182-8191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":154,"title":["Therapeutic use of curcumin\u2010encapsulated and curcumin\u2010primed exosomes"],"prefix":"10.1002","volume":"234","author":[{"given":"Mohammad N.","family":"Oskouie","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical 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