{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:03:06Z","timestamp":1773921786756,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T00:00:00Z","timestamp":1539475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetes mellitus (DM) is closely associated with male infertility and sexual dysfunction. Recent data indicate that the proinsulin C\u2010peptide (CP) exerts important physiological effects and shows the characteristics of an endogenous peptide hormone. So, this study was done to investigate the effect of C\u2010peptide with or without insulin treatment on testicular function and architecture in diabetic rats. Rats were divided into the following groups: control, diabetic, and diabetic groups treated with either CP alone or combined with insulin. Tested parameters included, estimation of serum follicle\u2010stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and glucose levels, testicular samples for histopathology and estimation of malondialdehyde (MDA), total antioxidant capacity (TAC), and B\u2010cell leukemia\/lymphoma\u20102 (BCL\u20102) levels as well as sperm count and motility. Results showed that DM caused a severe alteration in hormonal profile and reduced sperm parameters along with increased MDA and decrease in both TAC and BCL\u20102 levels. CP alone or with insulin treatment efficiently reversed all the negative effects of DM on rat testes, with maximum improvement in the combined regimen. Proposed mechanisms may involve its hypoglycemic, antioxidant, and antiapoptotic properties. Thus, CP could substitute for or better combined with insulin to prevent or retard diabetic\u2010induced testicular dysfunction.<\/jats:p>","DOI":"10.1002\/jcp.27618","type":"journal-article","created":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T10:40:43Z","timestamp":1539513643000},"page":"9351-9357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Proinsulin C\u2010peptide as an alternative or combined treatment with insulin for management of testicular dysfunction and fertility impairments in streptozotocin\u2010induced type 1 diabetic male rats"],"prefix":"10.1002","volume":"234","author":[{"given":"Walaa Hassan","family":"Nazmy","sequence":"first","affiliation":[{"name":"Physiology Department, Faculty of Medicine Minia University Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1408-1131","authenticated-orcid":false,"given":"Eman Abdelmonem","family":"Elbassuoni","sequence":"additional","affiliation":[{"name":"Physiology Department, Faculty of Medicine Minia University Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma Farrag","family":"Ali","sequence":"additional","affiliation":[{"name":"Physiology Department, Faculty of Medicine Minia University Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rehab Ahmed","family":"Rifaai","sequence":"additional","affiliation":[{"name":"Histology and Cell Biology Department, Faculty of Medicine Minia University Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,14]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i5.689"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7036.97.1.24"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/153573"},{"issue":"1","key":"e_1_2_6_1_5_1","first-page":"1","article-title":"Oxidative stress and antioxidants in male infertility: A difficult balance","volume":"3","author":"Agarwal A.","year":"2005","journal-title":"Iranian Journal of Reproductive Medicine"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60602-5"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem077"},{"issue":"4","key":"e_1_2_6_1_8_1","first-page":"12","article-title":"Effect of c\u2010peptide alone or in combination with nicotinamide on glucose and insulin levels in streptozotocin\u2013nicotinamide\u2010induced type 2 diabetic mice","volume":"21","author":"Ahangarpour A.","year":"2014","journal-title":"The Malaysian Journal of Medical Sciences"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2010.68"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.1.1.6843"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.01.011"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2006.06.006"},{"issue":"1","key":"e_1_2_6_1_13_1","first-page":"371","article-title":"Diabetes mellitus and influences on human fertility","volume":"9","author":"Basmatzou T.","year":"2016","journal-title":"International Journal"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0039"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5487.2122"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080020"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.150844"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0693-5"},{"key":"e_1_2_6_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2013.00083.x"},{"key":"e_1_2_6_1_20_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i1.145"},{"key":"e_1_2_6_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.11.002"},{"key":"e_1_2_6_1_22_1","first-page":"92","volume-title":"Institutional Animal Care and Use Committee Guidebook","author":"U. S. Department of Human and Health Services","year":"1992"},{"key":"e_1_2_6_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.09.015"},{"key":"e_1_2_6_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00402543"},{"key":"e_1_2_6_1_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00267630"},{"key":"e_1_2_6_1_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.4164"},{"key":"e_1_2_6_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.389"},{"key":"e_1_2_6_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2010.10.005"},{"key":"e_1_2_6_1_29_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.108.007260"},{"key":"e_1_2_6_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_2_6_1_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S79885"},{"key":"e_1_2_6_1_32_1","first-page":"91","article-title":"Studies on the diabetogenic action of streptozotocin (NSC\u201037917)","volume":"29","author":"Rakieten N.","year":"1963","journal-title":"Cancer Chemotherapy Reports"},{"key":"e_1_2_6_1_33_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339908783502398"},{"key":"e_1_2_6_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2012.06.004"},{"key":"e_1_2_6_1_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2006.00682.x"},{"key":"e_1_2_6_1_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1527"},{"key":"e_1_2_6_1_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.5.1497"},{"key":"e_1_2_6_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2007.12.006"},{"key":"e_1_2_6_1_39_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.111.013193"},{"key":"e_1_2_6_1_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2011.01228.x"},{"key":"e_1_2_6_1_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-2068"},{"key":"e_1_2_6_1_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1423"},{"key":"e_1_2_6_1_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.212530"},{"issue":"1","key":"e_1_2_6_1_44_1","first-page":"A337","article-title":"Activation of glucose metabolism by C\u2010peptide in patients with type 1 diabetes mellitus and in healthy control subjects","volume":"56","author":"Wilhelm B.","year":"2007","journal-title":"Diabetes"},{"key":"e_1_2_6_1_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00130.2014"},{"key":"e_1_2_6_1_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12670"},{"key":"e_1_2_6_1_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00418346"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.27618","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.27618","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.27618","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.27618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T20:19:37Z","timestamp":1692649177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.27618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,14]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/jcp.27618"],"URL":"https:\/\/doi.org\/10.1002\/jcp.27618","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,14]]},"assertion":[{"value":"2018-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}