{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:57:44Z","timestamp":1777388264927,"version":"3.51.4"},"reference-count":67,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T00:00:00Z","timestamp":1539475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sapienza University of Rome, Italy","award":["Ateneo Grant no. C26A147EE2 to AB."],"award-info":[{"award-number":["Ateneo Grant no. 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When mice were returned to a normal light\u2010dark regimen for 10 days, a slight, spontaneous improvement occurred, whereas a quick and almost complete recovery from PCOS signs and symptoms was obtained by treating animals with a daily supplementation of 420\u2009mg\/kg myo\u2010inositol and D\u2010chiro\u2010inositol (MyoIns\/DCIns) in a 40:1 molar ratio. Namely, ovaries from mice treated by this protocol recovered normal histological features and a proper ratio of theca\/granulosa cell layer thickness (TGR), suggesting that the androgenic phenotype was efficiently reversed. Indeed, we identified TGR as a useful index of PCOS, as its increase in PCOS\u2010modeled mice correlated linearly with reduced reproductive capability (\n<jats:italic>r<\/jats:italic>\u2009=\u20090.75, \n<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Mice treated with a 40:1 formula regained low TGR values and faster recovery of their fertility, with a physiological delivery time after mating. On the other hand, a higher D\u2010chiro\u2010inositol treatment formula, such as MyoIns versus DCIns 5:1, was ineffective or even had a negative effect on clinical\u2010pathological outcomes.<\/jats:p>","DOI":"10.1002\/jcp.27623","type":"journal-article","created":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T10:15:08Z","timestamp":1539512108000},"page":"9387-9398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Myo\u2010inositol and D\u2010chiro\u2010inositol (40:1) reverse histological and functional features of polycystic ovary syndrome in a mouse model"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8889-2634","authenticated-orcid":false,"given":"Arturo","family":"Bevilacqua","sequence":"first","affiliation":[{"name":"Department of Dynamic and Clinical Psychology Sapienza University of Rome and Research Center in Neurobiology Daniel Bovet\u201d (CRiN) Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Dragotto","sequence":"additional","affiliation":[{"name":"Department of Psychology Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Department of Environment and Primary Prevention, Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"Bizzarri","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine Sapienza University of Rome, Systems Biology Group Lab Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,14]]},"reference":[{"key":"e_1_2_7_1_2_1","first-page":"pp. 259","volume-title":"Androgen Excess Disorders in Women","author":"Abbott D. 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