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In this study, we investigated the impact of high fat (HF) diet in the myocardial susceptibility to I\/R injury, as well as in the expression of miRNA\u201029b. Isolated heart experiments using the ex vivo Langendorff perfusion model were used to induce cardiac I\/R injury. HF diet\u2010induced cardiac hypertrophy and impaired cardiac functional recovery after I\/R. miRNA\u201029b, which targets Col1, was reduced in the heart of HF diet\u2010fed mice, whereas the cardiac expression of Col1 was increased. In addition, hypoxia\u2013reoxygenation (H\/R) reduced the expression of miRNA\u201029b in cardiomyoblasts cultures. However, the overexpression of miRNA\u201029b in cardiomyoblasts reduced p53 mRNA levels and H\/R injury, suggesting that downregulation of miRNA\u201029b may be involved in I\/R injury. Together, our findings suggest that the reduced expression of miRNA\u201029b may be involved in the deteriorated cardiac functional recovery following I\/R in obese mice.<\/jats:p>","DOI":"10.1002\/jcp.27624","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T11:09:24Z","timestamp":1540552164000},"page":"9399-9407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["High fat diet reduces the expression of miRNA\u201029b in heart and increases susceptibility of myocardium to ischemia\/reperfusion injury"],"prefix":"10.1002","volume":"234","author":[{"given":"Elaine Castilho","family":"Guedes","sequence":"first","affiliation":[{"name":"Department of Anatomy Laboratory of Cell Biology and Functional Anatomy, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivson Bezerra","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Anatomy Laboratory of Cell Biology and Functional Anatomy, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo Brazil"},{"name":"Department of Morphology  Health Sciences Center, Federal University of Paraiba Joao Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Morais","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Anatomy Laboratory of Cell Biology and Functional Anatomy, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane B.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Anatomy Laboratory of Cell Biology and Functional Anatomy, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rud\u00e1 P.","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Department of Anatomy Laboratory of Integrative Systems Biology, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C. 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