{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:17:24Z","timestamp":1767136644701,"version":"build-2238731810"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed at investigating the effect of microRNA\u2010150 (miR\u2010150) on cell proliferation of Burkitt lymphoma and its molecular mechanism. Gene expression analysis was applied to identify target genes of miR\u2010150 in Burkitt lymphoma cell line ST486 based on the dataset from the Gene Expression Omnibus (GEO) datasets GSE86432. miRNA mimics, inhibitor and small interfering RNA (siRNA) were fluorescently labeled by Cy3, whereas plasmid vector was labeled by EGFP. Cells were viewed by \ufb02uorescence microscope and transfection efficiency was evaluated through fluorescent cell percentage. Quantitative real\u2010time polymerase chain reaction analysis (qRT\u2010PCR) and western blot were applied to detect the expression level of miR\u2010150 and\n                    <jats:italic>LMO4<\/jats:italic>\n                    . Cell proliferation, cell cycle, and apoptosis were explored by CCK\u20108, flow cytometry. Targeting relationship was validated by the Luciferase reporter assay. Tumor xenograft and immunohistochemical analysis were conducted in nude mice model. In Burkitt lymphoma cells, miR\u2010150 expression was significantly lower than normal ones, whereas the expression of\n                    <jats:italic>LMO4<\/jats:italic>\n                    was upregulated. miR\u2010150 might inhibit cell proliferation and promoted apoptosis in Burkitt lymphoma deterioration by downregulating\n                    <jats:italic>LMO4<\/jats:italic>\n                    . The results of tumor xenograft further confirmed the role of miR\u2010150 in Burkitt lymphoma. Targeting\n                    <jats:italic>LMO4<\/jats:italic>\n                    is a significant mechanism by which miR\u2010150 suppresses cell growth and promotes apoptosis in Burkitt lymphoma cells, thus may provide a novel target for Burkitt lymphoma therapy in the future.\n                  <\/jats:p>","DOI":"10.1002\/jcp.27652","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T09:30:18Z","timestamp":1542101418000},"page":"9652-9662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["<i>Retracted<\/i>\n                    : miR\u2010150 might inhibit cell proliferation and promote cell apoptosis by targeting\n                    <i>LMO4<\/i>\n                    in Burkitt lymphoma"],"prefix":"10.1002","volume":"234","author":[{"given":"Dandan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanshuan","family":"Wei","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Henan No. 2 Provincial People\u2019s Hospital Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guannan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 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