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Genomic analysis studies have connected main components of the phosphoinositide\u20103\u2010kinase (PI3K) signalling pathway to BTC. PI3K pathway playing a central role in cell signalling and being deregulated in various tumours has been studied as a target for chemotherapy. Novel compounds have also been identified in preclinical trials that specifically target the PI3K pathway in BTCs, but these studies have not accelerated to clinical use. These novel compounds can be examined in upcoming studies to validate them as potential therapeutic agents, as further research is required to combat the growing need for adjuvant chemotherapy to successfully battle this tumour type. Furthermore, these molecules could also be used along with gemcitabine, cisplatin and 5\u2010fluorouracil to improve sensitivity of the tumour tissue to chemotherapy. This review focuses on the basics of PI3K signalling, genetic alterations of this pathway in BTCs and current advancement in targeting this pathway in BTCs. It emphasizes the need for gene\u2010based drug screening in BTC. It may reveal various novel targets and drugs for amelioration of survival in patients with BTC and serve as a stepping stone for further research.<\/jats:p>","DOI":"10.1002\/jcp.27673","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T04:51:46Z","timestamp":1540788706000},"page":"8259-8273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Targeting phosphoinositide\u20103\u2010kinase pathway in biliary tract cancers: A remedial route?"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8378-6197","authenticated-orcid":false,"given":"Jayaramayya","family":"Kaavya","sequence":"first","affiliation":[{"name":"Department of Zoology Avinashilingam Institute for Home Science and Higher Education for Women, Avinashilingam University for Women Coimbatore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iyer","family":"Mahalaxmi","sequence":"additional","affiliation":[{"name":"Department of Zoology Avinashilingam Institute for Home Science and Higher Education for Women, Avinashilingam University for Women Coimbatore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subramaniam Mohana","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Biology Sankara Nethralaya Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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