{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:41:09Z","timestamp":1791906069347,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011447","name":"Science and Technology Department of Henan Province","doi-asserted-by":"publisher","award":["142300410264"],"award-info":[{"award-number":["142300410264"]}],"id":[{"id":"10.13039\/501100011447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute myocardial infarction (AMI), as a severe consequence of coronary atherosclerotic heart disease, always contributes to the loss of myocardial cells. Mounting evidence shows that annexin protects the myocardium from ischemic injury. In this study, we examine the inhibition of annexin A3 (ANXA3) on AMI through the phosphatidylinositide 3\u2010kinase\/protein kinase B (PI3K\/Akt) signaling pathway. We selected rats to build an AMI model which was then assigned into different groups. The hemodynamic parameters after transfection were detected by using enzyme\u2010linked immunosorbent assay. The effect of silencing of ANXA3 on inflammatory reaction and the PI3K\/Akt signaling pathway was assessed. Rats transfected with ANXA3\u2010short hairpin RNA had alleviated hemodynamics, inflammatory reaction, decreased infarct size, \u03b1\u2010smooth muscle actin, Collagen I, and Collagen III as well as an increased vascular endothelial growth factor. Silencing ANAX3 would promote repair and healing of myocardial tissue by activation of the PI3K\/Akt signaling pathway. Collectively, our study provides evidence that the downregulation of ANXA3 promotes the repair and healing of myocardial tissues by activating the PI3K\/Akt signaling pathway.<\/jats:p>","DOI":"10.1002\/jcp.27717","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T04:41:59Z","timestamp":1542688919000},"page":"10535-10546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Annexin A3 gene silencing promotes myocardial cell repair through activation of the PI3K\/Akt signaling pathway in rats with acute myocardial infarction"],"prefix":"10.1002","volume":"234","author":[{"given":"Hua","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Cardiology Henan Provincial People's Hospital, Fuwai Central China Cardiovascular Hospital Zhengzhou 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