{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:42:55Z","timestamp":1790242975887,"version":"4.1.0"},"reference-count":105,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470434"],"award-info":[{"award-number":["81470434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Apelin is an endogenous ligand of seven\u2010transmembrane G\u2010protein\u2010coupled receptor APJ. Apelin and APJ are distributed in various tissues, including the heart, lung, liver, kidney, and gastrointestinal tract and even in tumor tissues. Studies show that apelin messenger RNA is widely expressed in gastrointestinal (GI) tissues, including stomach and small intestine, which is closely correlated with GI function. Thus, the apelin\/APJ system may exert a broad range of activities in the digestive system. In this paper, we review the role of the apelin\/APJ system in the digestive system in physiological conditions, such as gastric acid secretion, control of appetite and food intake, cell proliferation, cholecystokinin secretion and histamine release, gut\u2013brain axis, GI motility, and others. In pathological conditions, the apelin\/APJ system plays an important role in the healing process of stress gastric injury, the clinical features and prognosis of patients with gastric cancers, the reduction of inflammatory response to enteritis and pancreatitis, the mediation of liver fibrogenesis, the promotion of liver damage, the inhibition of liver regeneration, the contribution of splanchnic neovascularization in portal hypertension, the treatment of colon cancer, and GI oxidative damage. Overall, the apelin\/APJ system plays diversified functions and regulatory roles in digestive physiology and pathology. Further exploration of the relationship between the apelin\/APJ system and the digestive system will help to find new and effective drugs for treating and alleviating the pain of digestive diseases.<\/jats:p>","DOI":"10.1002\/jcp.27720","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T00:06:00Z","timestamp":1541203560000},"page":"7796-7810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Function and regulation of apelin\/APJ system in digestive physiology and pathology"],"prefix":"10.1002","volume":"234","author":[{"given":"Zhen","family":"Huang","sequence":"first","affiliation":[{"name":"Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics University of South China Hengyang China"},{"name":"Department of Pharmacy The First Affiliated Hospital, University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuling","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2787-3018","authenticated-orcid":false,"given":"Linxi","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,2]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-578781"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2010.05.008"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr3103w"},{"issue":"3","key":"e_1_2_8_1_5_1","first-page":"403","article-title":"The role of apelin in the modulation of gastric and pancreatic enzymes activity in adult rats","volume":"67","author":"Antuschevich H.","year":"2016","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.05.012"},{"issue":"4","key":"e_1_2_8_1_7_1","first-page":"423","article-title":"Influence of fundectomy and intraperitoneal or intragastric administration of apelin on apoptosis, mitosis, and DNA repair enzyme OGG1,2 expression in adult rats gastrointestinal tract and pancreas","volume":"64","author":"Antushevich H.","year":"2013","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2014.11.011"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.191122"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-016-0469-9"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2018.03.005"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2016.12.001"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00223.2017"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00145.2015"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450115666141128120053"},{"key":"e_1_2_8_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-011-9507-9"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21904"},{"key":"e_1_2_8_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-012-3210-7"},{"key":"e_1_2_8_1_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2016.3391"},{"issue":"10","key":"e_1_2_8_1_20_1","first-page":"3343","article-title":"Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis","volume":"118","author":"Chun H. 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