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Although great efforts have been made to treat the disease, effective drugs against metastatic melanoma still lack at the clinical setting. In the current study, we found that lycorine, a small molecule of isoquinoline alkaloid, significantly suppressed melanoma cell migration and invasion in vitro, and decreased the metastasis of melanoma cells to lung tissues in tumor\u2010bearing mice, resulting in significant prolongation of the survival of the mice without obvious toxicity. Molecular mechanistic studies revealed that lycorine significantly reduced intracellular levels of \u03b2\u2010catenin protein through degradation of the protein via the ubiquitin\u2013proteasome pathway, and decreased the expression of \u03b2\u2010catenin downstream prometastatic matrix metallopeptidase 9 and Axin2 genes. Collectively, our findings support the notion that targeting the oncogenic \u03b2\u2010catenin by lycorine is a new option to inhibit melanoma cell metastasis, providing a good drug candidate potential for development novel therapeutics against metastatic melanoma.<\/jats:p>","DOI":"10.1002\/jcp.27732","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T15:13:48Z","timestamp":1545232428000},"page":"10566-10575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Lycorine inhibits melanoma cell migration and metastasis mainly through reducing intracellular levels of \u03b2\u2010catenin and matrix metallopeptidase 9"],"prefix":"10.1002","volume":"234","author":[{"given":"Pan","family":"Zhang","sequence":"first","affiliation":[{"name":"Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, 2011 Collaborative Innovation Center of Hematology, Soochow University Suzhou Jiangsu P. 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