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Nevertheless, whether the circular RNAs were related in Hirschsprung's disease (HSCR) remains unknown. Thus, we discovered the cir\u2010CCDC66 was downregulated in HSCR compared with the normal gut tissues. The cir\u2010CCDC66 reduction might inhibit cells\u2019 proliferation and migration in vitro. Then, we found that DCX transcript was putative cir\u2010CCDC66 competing endogenous RNA. Furthermore, the function of cir\u2010CCDC66 as a sponge for miR\u2010488\u20103p to regulate DCX RNA expression was demonstrated by immunoprecipitation and luciferase reporter assays. In conclusion, this is the first report revealing that cir\u2010CCDC66 modulates DCX expression through sponging miR\u2010488\u20103p and thus participates in the onset of HSCR.<\/jats:p>","DOI":"10.1002\/jcp.27733","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T06:24:48Z","timestamp":1542349488000},"page":"10576-10587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Circular RNA CCDC66 targets DCX to regulate cell proliferation and migration by sponging miR\u2010488\u20103p in Hirschsprung's disease"],"prefix":"10.1002","volume":"234","author":[{"given":"Zechao","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Children's Hospital of Nanjing Medical University Nanjing China"},{"name":"State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University Nanjing 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