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This study aims to evaluate the regulatory roles of interleukin\u20101 receptor\u2010associated kinase 3 (IRAK3) and\u00a0nuclear factor\u2010\u03baB (NF\u2010\u03baB) signaling pathway in cardiac rupture and ventricular remodeling. Microarray analysis was performed to screen AMI\u2010related differentially expressed genes and IRAK3 was identified. The models of AMI were established in male C57BL\/6 mice to investigate the functional role of IRAK3. Afterwards, lentivirus recombinant plasmid si\u2010IRAK3 was constructed for IRAK3 silencing. Next, cardiac function parameters were measured in response to IRAK3 silencing. The regulatory effects that IRAK3 had on myocardial infarct size and the content of myocardial interstitial collagen were analyzed. The regulation of IRAK3 silencing on the NF\u2010\u03baB signaling pathway was further assayed. The obtained results indicated that highly expressed IRAK3 and activated NF\u2010\u03baB signaling pathway were observed in myocardial tissues of mouse models of AMI, accompanied by increased expression of matrix metalloproteinase (MMP)\u20102\/9 and tissue inhibitor of metalloproteinase 2 (TIMP\u20102). Notably, IRAK3 gene silencing inhibited the activation of NF\u2010\u03baB signaling pathway. Furthermore, IRAK3 gene silencing led to the decreased thickness of infarct area and collagen content of myocardial interstitium, alleviated diastolic, and systolic dysfunctions, as well as, facilitated cardiac functions in mice with AMI, corresponding to decreased expression of MMP\u20102\/9 expression and increased expression of TIMP\u20102. Taken together, silencing of IRAK3 inactivates the NF\u2010\u03baB signaling pathway, and thereby impeding the cardiac rupture and ventricular remodeling, which eventually prevents AMI progression.<\/jats:p>","DOI":"10.1002\/jcp.27827","type":"journal-article","created":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T05:28:29Z","timestamp":1544246909000},"page":"11722-11733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["<i>Retracted<\/i>: IRAK3 gene silencing prevents cardiac rupture and ventricular remodeling through negative regulation of the NF\u2010\u03baB signaling pathway in a mouse model of acute myocardial infarction"],"prefix":"10.1002","volume":"234","author":[{"given":"Zhen\u2010Wei","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Henan Provincial People\u2019s Hospital Zhengzhou P. R. 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