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To achieve tumor selectivity, two main modifications on Ads genome have been applied: small deletions and insertion of tissue\u2010 or tumor\u2010specific promoters. Despite oncolytic adenoviruses ability in tumor cell lysis and immune responses stimulation, to further increase their antitumor effects, genomic modifications have been carried out including insertion of checkpoint inhibitors and antigenic or immunostimulatory molecules into the adenovirus genome and combination with dendritic cells and chemotherapeutic agents. 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