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Also during tooth development, parathyroid hormone\u2010related peptide (PTHrP) is expressed surrounding the tooth germ. Thus, we aimed to investigate the effect of PTHrP (1\u201334) on bone resorption and osteogenesis of DFCs in vitro and in vivo. In vitro studies demonstrated that DFCs cocultured with HERS cells expressed higher levels of\u00a0BSP and OPN than the DFCs control group, whereas cocultured DFCs treated with PTHrP (1\u201334) had lower expressions of ALP, RUNX2, BSP, and OPN than the cocultured DFCs control group. Moreover, we found PTHrP (1\u201334) inhibited osteogenesis of cocultured DFCs by inactivating the Wnt\/\u03b2\u2010catenin pathway. PTHrP (1\u201334) also increased the expression of RANKL\/OPG ratio in DFCs. Consistently, in vivo study found that PTHrP (1\u201334) accelerated tooth eruption and inhibited alveolar bone formation. Therefore, these results suggest that PTHrP (1\u201334) accelerates tooth eruption and inhibits osteogenesis of DFCs by inactivating Wnt\/\u03b2\u2010catenin pathway.<\/jats:p>","DOI":"10.1002\/jcp.27857","type":"journal-article","created":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T06:26:23Z","timestamp":1545719183000},"page":"11900-11911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Parathyroid hormone\u2010related peptide (1\u201334) promotes tooth eruption and inhibits osteogenesis of dental follicle cells during tooth development"],"prefix":"10.1002","volume":"234","author":[{"given":"Jiawei","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University Chengdu China"},{"name":"National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University Chengdu 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