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NSAIDs and other GCs are effective in alleviating the pain, inflammation, and stiffness due to RA. DMARDs that are used for RA therapy are hydroxychloroquine, methotrexate, leflunomide, and sulfasalazine. The biological therapies, on the contrary, are chimeric anti\u2010CD20 monoclonal antibody, rituximab, inhibitors of tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) like etanercept, infliximab, and adalimumab, a recombinant inhibitor of interleukin\u20101 (IL\u20101), anakinra, and costimulation blocker, abatacept. Moreover, newly under evaluation biological therapies include new TNF\u2010\u03b1 inhibitors, JAK inhibitors, anti\u2010interleukin\u20106\u2010receptor monoclonal antibodies (mABs), and antibodies against vital molecules involved in the survival and development of functional B cells. The new strategies to treat RA has improved the course of the disease and most of the patients are successful in remission of the clinical manifestations if the diagnosis of the disease occur early. The probability of remission increase if the diagnosis happens rapidly and treat\u2010to\u2010target approach are implemented. In this review article, we have attempted to go through the treatment strategies for RA therapy both the routine ones and those which have been developed over the past few years and currently under investigation.<\/jats:p>","DOI":"10.1002\/jcp.27860","type":"journal-article","created":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T05:22:32Z","timestamp":1544246552000},"page":"10018-10031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":396,"title":["Strategies toward rheumatoid arthritis therapy; the old and the new"],"prefix":"10.1002","volume":"234","author":[{"given":"Mojtaba","family":"Abbasi","sequence":"first","affiliation":[{"name":"Veterinary Medicine, Faculty of Veterinary Medicine Shahrekord Branch, Islamic Azad University Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4849-6706","authenticated-orcid":false,"given":"Mohammad Javad","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Department of Immunology and Allergy Faculty of Medicine, Bushehr University of Medical Sciences Bushehr Iran"},{"name":"Department of Immunology School of Medicine, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirous","family":"Jamalzehi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences Iranshahr University of Medical Sciences Iranshahr Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Alimohammadi","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine, Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam Hasanzadeh","family":"Bezvan","sequence":"additional","affiliation":[{"name":"Department of Microbiology Shahr\u2010e\u2010Qods Branch, Islamic Azad University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0736-6211","authenticated-orcid":false,"given":"Hamed","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine, Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Student Research Committee, Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0429-8329","authenticated-orcid":false,"given":"Saeed","family":"Aslani","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,7]]},"reference":[{"key":"e_1_2_12_1_2_1","first-page":"979","article-title":"Etiology and pathogenesis of rheumatoid arthritis","author":"Albani S.","year":"1997","journal-title":"Arthritis and Allied Conditions"},{"key":"e_1_2_12_1_3_1","first-page":"564","article-title":"Infection and rheumatoid arthritis: Guilt by association?","volume":"27","author":"Albert L. 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