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At present, the treatment target of these diseases is to interfere with osteoclastic formation and function. Scutellarein (Scu), a flavonoids compound, can inhibit the progress of tumor and inflammation. However, the role of Scu in inflammatory osteolysis isn\u2019t elucidated clearly. Our study showed that Scu inhibited bone destruction induced by LPS in vivo and OC morphology and function induced by RANKL in vitro. Mechanistic studies revealed that Scu suppressed osteoclastic marker gene expression by RANKL\u2010induced, such as<jats:italic>Ctsk9<\/jats:italic>,<jats:italic>Mmp9<\/jats:italic>,<jats:italic>Acp5<\/jats:italic>, and<jats:italic>Atp6v0d2<\/jats:italic>. In addition, we found that the inhibition effects of osteoclastogenesis and bone resorption function of Scu were mediated via attenuating NF\u2010\u03baB and NFAT signaling pathways. In conclusion, the results showed that Scu may become a potential new drug for the treatment of inflammatory osteolysis.<\/jats:p>","DOI":"10.1002\/jcp.27888","type":"journal-article","created":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T06:45:05Z","timestamp":1544856305000},"page":"11951-11959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Scutellarein inhibits RANKL\u2010induced osteoclast formation in vitro and prevents LPS\u2010induced bone loss in vivo"],"prefix":"10.1002","volume":"234","author":[{"given":"Fangsheng","family":"Fu","sequence":"first","affiliation":[{"name":"Research Centre for Regenerative Medicine, Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Shao","sequence":"additional","affiliation":[{"name":"Research Centre for Regenerative Medicine, Guangxi 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