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LGMDs are autosomal disorders with different types and their prevalence is not the same in different areas. New technologies such as next\u2010generation sequencing can accelerate their diagnosis. Several important pathological mechanisms that are involved in the pathology of the LGMD include abnormalities in dystrophin\u2013glycoprotein complex, the sarcomere, glycosylation of dystroglycan, vesicle and molecular trafficking, signal transduction pathways, and nuclear functions. Here, we provide a comprehensive review that integrates LGMD clinical manifestations, prevalence, and some pathological mechanisms involved in LGMDs.<\/jats:p>","DOI":"10.1002\/jcp.27907","type":"journal-article","created":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T00:26:57Z","timestamp":1544228817000},"page":"7874-7884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Prevalence, pathological mechanisms, and genetic basis of limb\u2010girdle muscular dystrophies: A review"],"prefix":"10.1002","volume":"234","author":[{"given":"Eskandar","family":"Taghizadeh","sequence":"first","affiliation":[{"name":"Cellular and Molecular Research Center Yasuj University of Medical Sciences Yasuj Iran"},{"name":"Department of Medical Genetics, Faculity of Medicine Mashhad University of Medical Science Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Rezaee","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-1971","authenticated-orcid":false,"given":"George E.","family":"Barreto","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Facultad de Ciencias Pontificia Universidad Javeriana Bogot\u00e1 D.C Colombia"},{"name":"Instituto de Ciencias Biom\u00e9dicas, Universidad Aut\u00f3noma de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center Pharmaceutical Technology Institute, Mashhad University of Medical Science Mashhad Iran"},{"name":"Neurogenic Inflammation Research Center Mashhad University of Medical Science Mashhad Iran"},{"name":"School of Pharmacy, Mashhad University of Medical Science Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,7]]},"reference":[{"key":"e_1_2_13_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2017.02.015"},{"key":"e_1_2_13_1_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2018.1508997"},{"key":"e_1_2_13_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2016.05.003"},{"key":"e_1_2_13_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2005.01.013"},{"key":"e_1_2_13_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2004.03.001"},{"key":"e_1_2_13_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01573"},{"key":"e_1_2_13_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/1689"},{"key":"e_1_2_13_1_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/rjim-2015-0002"},{"key":"e_1_2_13_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2008.08.005"},{"key":"e_1_2_13_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880060702"},{"key":"e_1_2_13_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.09.066"},{"key":"e_1_2_13_1_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/324412"},{"key":"e_1_2_13_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.05.028"},{"key":"e_1_2_13_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2013.12.011"},{"key":"e_1_2_13_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90051-5"},{"key":"e_1_2_13_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.05.009"},{"key":"e_1_2_13_1_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-101487"},{"key":"e_1_2_13_1_19_1","first-page":"1","article-title":"The limb\u2013girdle muscular dystrophies: Is treatment on the horizon?","author":"Chu M. 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