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Here, we hypothesized that these diabetogenic effects of pravastatin could be counteracted by treatment with the antioxidant coenzyme Q\n<jats:sub>10<\/jats:sub> (CoQ\n<jats:sub>10<\/jats:sub>), an intermediate generated in the cholesterol synthesis pathway. LDLr\n<jats:sup>\u2212\/\u2212<\/jats:sup> mice were treated with pravastatin and\/or CoQ\n<jats:sub>10<\/jats:sub> for 2 months. Pravastatin treatment resulted in a 75% decrease of liver CoQ\n<jats:sub>10<\/jats:sub> content. Dietary CoQ\n<jats:sub>10<\/jats:sub> supplementation of pravastatin\u2010treated mice reversed fasting hyperglycemia, improved glucose tolerance (20%) and insulin sensitivity (&gt;2\u2010fold), and fully restored islet glucose\u2010stimulated insulin secretion impaired by pravastatin (40%). Pravastatin had no effect on insulin secretion of wild\u2010type mice. In vitro, insulin\u2010secreting INS1E cells cotreated with CoQ\n<jats:sub>10<\/jats:sub> were protected from cell death and oxidative stress induced by pravastatin. Simvastatin and atorvastatin were more potent in inducing dose\u2010dependent INS1E cell death (10\u201315\u2010fold), which were also attenuated by CoQ\n<jats:sub>10<\/jats:sub> cotreatment. Together, these results demonstrate that statins impair \u03b2\u2010cell redox balance, function and viability. However, CoQ\n<jats:sub>10<\/jats:sub> supplementation can protect the statins detrimental effects on the endocrine pancreas.<\/jats:p>","DOI":"10.1002\/jcp.27932","type":"journal-article","created":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T05:28:16Z","timestamp":1544246896000},"page":"11047-11059","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Coenzyme Q<sub>10<\/sub> protects against \u03b2\u2010cell toxicity induced by pravastatin treatment of hypercholesterolemia"],"prefix":"10.1002","volume":"234","author":[{"given":"Estela","family":"Lorza\u2010Gil","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology Biology Institute, State University of Campinas Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6687-2819","authenticated-orcid":false,"given":"Jane C.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology Biology Institute, State University of Campinas Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garc\u00eda\u2010Ar\u00e9valo","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology Biology Institute, State University of Campinas Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean F.","family":"Vettorazzi","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology Biology Institute, State University of Campinas Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology Biology Institute, State University of Campinas Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro G.","family":"Salerno","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology Biology Institute, State University of Campinas Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Roberto","family":"Trigo","sequence":"additional","affiliation":[{"name":"Department of Animal Biology Biology Institute, State University of Campinas Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-6992","authenticated-orcid":false,"given":"Helena C. 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