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The nuclear receptor peroxisome proliferator\u2010activated receptor \u03b4 (PPAR\u03b4) is involved in the regulation of cardiac lipid metabolism. Here, we describe a novel PPAR\u03b4\u2010dependent molecular cascade involving microRNA\u201029a (miR\u201029a) and atrial natriuretic factor (ANF), which is reactivated in cardiac hypertrophy. In addition, we identify a novel role of miR\u201029a, in which it has a cardioprotective function in isoproterenol hydrochloride\u2010induced cardiac hypertrophy by targeting PPAR\u03b4 and downregulating ANF. Finally, we provide evidence that miR\u201029a reduces the isoproterenol hydrochloride\u2010induced cardiac hypertrophy response, thereby underlining the potential clinical relevance of miR\u201029a in which it may serve as a potent therapeutic target for heart hypertrophy treatment.<\/jats:p>","DOI":"10.1002\/jcp.27997","type":"journal-article","created":{"date-parts":[[2018,12,23]],"date-time":"2018-12-23T09:04:40Z","timestamp":1545555880000},"page":"13252-13262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["miR\u201029a attenuates cardiac hypertrophy through inhibition of PPAR\u03b4 expression"],"prefix":"10.1002","volume":"234","author":[{"given":"Si","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology School of Basic Medical Sciences, Zhengzhou University Zhengzhou City Henan Peoples's Republic of China"},{"name":"Department of Clinical Laboratory The Zhengzhou Central Hospital Affiliated to Zhengzhou University Zhengzhou City Henan Peoples's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongnan","family":"Yin","sequence":"additional","affiliation":[{"name":"Biobank, Peking University Third Hospital Beijing Peoples's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei\u2010Fei","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; 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