{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:44:33Z","timestamp":1790905473232,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370181"],"award-info":[{"award-number":["81370181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770089"],"award-info":[{"award-number":["81770089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic intermittent hypoxia (CIH) is known to induce hypertension, but the mechanism is not well understood. We hypothesized that sensory plasticity of the carotid body (CB) and oxidative stress in the paraventricular nucleus (PVN) are involved in CIH\u2010induced hypertension. In this study, rats were exposed to CIH for 28\u2009days (intermittent hypoxia of 21% O\n                    <jats:sub>2<\/jats:sub>\n                    for 60\u2009s and 5% O\n                    <jats:sub>2<\/jats:sub>\n                    for 30\u2009s, cyclically repeated for 8\u2009hr\/day) and then randomly grouped for intracerebroventricular injection of 5\u2010HT2 receptor antagonist ritanserin, Rho\u2010associated protein kinase (ROCK) inhibitor Y\u201027632, and NADPH oxidase (NOX) inhibitor diphenyleneiodonium (DPI), respectively. We found that CIH increased blood pressure (BP), elevated carotid sinus nerve (CSN) and renal sympathetic nerve (RSN) activities, oxidative stress, and cell apoptosis in PVN. NOX\u2010derived reactive oxygen species (ROS) production and cell apoptosis decreased when CIH\u2010induced activation of 5\u2010HT\/5\u2010HT2AR\/PKC signaling was inhibited by ritanserin. In addition, RhoA expression was downregulated when oxidative stress was attenuated by DPI, while Y\u201027632 decreased the expression of endothelin\u20101, which is overexpressed in the vascular wall during hypertension. Moreover, treatment with ritanserin, DPI or Y\u201027632 attenuated the sensory plasticity and sympathetic hyperactivity as well as CIH\u2010induced elevation of BP. In conclusion, CIH\u2010induced activation of 5\u2010HT\/5\u2010HT2AR\/PKC signaling contributes to NOX\u2010derived oxidative stress in PVN, which may cause sensory plasticity of CB, RSN hyperactivity, and elevated BP.\n                  <\/jats:p>","DOI":"10.1002\/jcp.28031","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T14:22:19Z","timestamp":1546611739000},"page":"13534-13543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia"],"prefix":"10.1002","volume":"234","author":[{"given":"Pei","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Respiratory Disease Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Mei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Emergency Department The Second Clinical College, Shenzhen People's Hospital, Jinan University Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7636-5730","authenticated-orcid":false,"given":"Ke","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Respiratory Disease Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010Fang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Respiratory Disease Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Respiratory Disease Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.10.025"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.1.8025776"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000112"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.045"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191762"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsx104"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2012.31"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2005.06.003"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.4161\/sgtp.28846"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-016-1449-2"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.114660"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0201k.x"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4768-08.2009"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1734109100"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00820.2003"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.273789"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.114033"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2006.036434"},{"key":"e_1_2_7_1_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2013.075432"},{"key":"e_1_2_7_1_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1884OC"},{"key":"e_1_2_7_1_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00043210"},{"key":"e_1_2_7_1_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.14.1906"},{"key":"e_1_2_7_1_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00592.2013"},{"key":"e_1_2_7_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00126-2"},{"key":"e_1_2_7_1_26_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13258"},{"key":"e_1_2_7_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00653-8"},{"key":"e_1_2_7_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.03.055"},{"key":"e_1_2_7_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.05.035"},{"key":"e_1_2_7_1_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440360178019"},{"key":"e_1_2_7_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.02.023"},{"key":"e_1_2_7_1_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf3204"},{"key":"e_1_2_7_1_33_1","first-page":"205","article-title":"Effect of mixed salt stress on malondialdehyde, proteins and antioxidant enzymes of Leymus chinensis in three leaf colors","volume":"86","author":"Zhou C.","year":"2017","journal-title":"Phyton\u2010International Journal of Experimental Botany"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.28031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.28031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.28031","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.28031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:48:25Z","timestamp":1787125705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.28031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,4]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/jcp.28031"],"URL":"https:\/\/doi.org\/10.1002\/jcp.28031","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,4]]},"assertion":[{"value":"2018-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}