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Currently, medications used for the prevention and treatment of peri\u2010implant osteolysis show serious side effects. Therefore, development for more effective new drugs with less side effects is extremely urgent. Vaccarin is a natural flavonoid extracted from\n                    <jats:italic>Vaccaria segetalis<\/jats:italic>\n                    , with various biological functions, including antioxidantory, anti\u2010inflammatory, and promotion of angiogenesis. However, the putative role of vaccarin in the inhibition of titanium particle\u2010induced osteolysis has not been reported. In this study, it was indicated that vaccarin could effectively inhibit RANKL\u2010induced osteoclastogenesis, fusion of F\u2010actin rings, bone resorption, and expression of osteoclast marker genes in a dose\u2010dependent manner in vitro. Moreover, vaccarin could also inhibit RANKL\u2010induced osteoclastogenesis via the inhibition of NF\u2010\u03baB and MAPK (p38, ERK, and JNK) signaling pathways, and inhibit the transcription of downstream transcription factors, such as c\u2010Fos and NFATc1. Consistent with in vitro results, this in vivo study showed that vaccarin exhibited an inhibitory effect on titanium particle\u2010induced osteolysis by antiosteoclastogenesis. In conclusion, vaccarin could be a promising agent for preventing and treating peri\u2010implant osteolysis.\n                  <\/jats:p>","DOI":"10.1002\/jcp.28063","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T00:05:36Z","timestamp":1547424336000},"page":"13832-13842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Vaccarin prevents titanium particle\u2010induced osteolysis and inhibits RANKL\u2010induced osteoclastogenesis by blocking NF\u2010\u03baB and MAPK signaling pathways"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8356-4500","authenticated-orcid":false,"given":"Yun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"},{"name":"Research Centre for Regenerative Medicine, Guangxi Key Laboratory of Regenerative 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