{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T08:25:55Z","timestamp":1787127955400,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T00:00:00Z","timestamp":1546819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T00:00:00Z","timestamp":1546819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lung cancer belongs to a leading popular and malignant cancer around the world. However, the root mechanism underlying lung cancer progression remains unclear. Recently, long noncoding RNA (lncRNA) has been identified as important for tumorigenesis. LncRNA MNX1\u2010AS1 is proven to regulate colon adenocarcinoma, cervical cancer, glioblastoma, and ovarian cancer. Whether MNX1\u2010AS1 participates in lung cancer needs investigation. In our research, we found that MNX1\u2010AS1 was dramatically upregulated in lung cancer. MNX1\u2010AS1 upregulation indicated poor prognosis in lung cancer patients. Functionally, MNX1\u2010AS1 promoted lung cancer progression through regulating proliferation, migration, and invasion. Mechanistically, MNX1\u2010AS1 was found to locate in the cytoplasm and interact with miR\u2010527. Through inhibiting miR\u2010527 availability, MNX1\u2010AS1 facilitated BRF2 expression. Restoration of BRF2 rescued defects of proliferation, migration, and invasion caused by MNX1\u2010AS1 knockdown. Taken together, our study found a novel signaling pathway, namely MNX1\u2010AS1\/miR\u2010527\/BRF2 axis, involved in lung cancer progression.<\/jats:p>","DOI":"10.1002\/jcp.28064","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T22:11:18Z","timestamp":1546985478000},"page":"13843-13850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Long noncoding RNA MNX1\u2010AS1 contributes to lung cancer progression through the miR\u2010527\/BRF2 pathway"],"prefix":"10.1002","volume":"234","author":[{"given":"Haibo","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Emergency Part 2 of the First Hospital, Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leng","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology China\u2013Japan Union Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery China\u2013Japan Union Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7946-0314","authenticated-orcid":false,"given":"Nan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery China\u2013Japan Union Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,7]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-10-47"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504018X15228909735079"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.9"},{"issue":"24","key":"e_1_2_6_1_5_1","first-page":"5618","article-title":"Overexpression of lncRNA MNX1\u2010AS1 is associated with poor clinical outcome in epithelial ovarian cancer","volume":"21","author":"Li A. 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