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Despite significant improvements in leukemia treatment, the efficacy of conventional chemotherapeutic agents is low and the disease carries a poor prognosis with frequent relapses and high mortality. Curcumin is a yellow polyphenol compound with diverse pharmacological actions including anticancer, antioxidant, antidiabetic, anti\u2010inflammatory, immunomodulatory, hepatoprotective, lipid\u2010regulating, antidepressant, and antiarthritic. Many cellular and experimental studies have reported the benefits of curcumin in treating leukemia. Curcumin's anticancer effects are exerted via various mechanisms. Here, we review the effects of curcumin on various types of leukemia whilst considering its mechanisms of action.<\/jats:p>","DOI":"10.1002\/jcp.28072","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T13:52:26Z","timestamp":1546609946000},"page":"12404-12414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Curcumin as a therapeutic agent in leukemia"],"prefix":"10.1002","volume":"234","author":[{"given":"Hamideh","family":"Kouhpeikar","sequence":"first","affiliation":[{"name":"Department of Hematology and Blood Bank Cancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-3917","authenticated-orcid":false,"given":"Alexandra E.","family":"Butler","sequence":"additional","affiliation":[{"name":"Diabetes Research Center, Qatar Biomedical Research Institute Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faeze","family":"Bamian","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Bank Cancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-1971","authenticated-orcid":false,"given":"George E.","family":"Barreto","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica Facultad de Ciencias, Pontificia Universidad Javeriana Bogot\u00e1 Colombia"},{"name":"Instituto de Ciencias Biom\u00e9dicas, Universidad Aut\u00f3noma de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Majeed","sequence":"additional","affiliation":[{"name":"Sabinsa Corporation East Windsor New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences Mashhad Iran"},{"name":"School of Pharmacy, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25778"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.1.143"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02973907"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.20.8931"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335850"},{"key":"e_1_2_9_1_7_1","first-page":"282","article-title":"Effects of water\u2010soluble antioxidants and MAPKK\/MEK inhibitor on curcumin\u2010induced apoptosis in HL\u201060 human leukemic cells","volume":"6","author":"Banjerdpongchai R.","year":"2005","journal-title":"Asian Pacific Journal of Cancer Prevention: APJCP"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.10.5753"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2007.05.005"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2001.5381"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-8-31"},{"issue":"2","key":"e_1_2_9_1_12_1","first-page":"210","volume":"41","author":"Chen J.","year":"2010","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2017.69326"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65248-0"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2014.09.006"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-017-2182-7"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2012.12.010"},{"issue":"9","key":"e_1_2_9_1_18_1","first-page":"2099","article-title":"Acute myeloid leukemia: Epidemiology and etiology. 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