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It is characterized by the development of a multitude of renal cysts, which leads to massive enlargement of the kidney and often to renal failure in adulthood. ADPKD is caused by a mutation in\n                    <jats:italic>PKD1<\/jats:italic>\n                    or\n                    <jats:italic>PKD2<\/jats:italic>\n                    genes encoding the proteins polycystin\u20101 and polycystin\u20102, respectively. Recent studies showed that cyst formation and growth result from deregulation of multiple cellular pathways like proliferation, apoptosis, metabolic processes, cell polarity, and immune defense. In ADPKD, intracellular cyclic adenosine monophosphate (cAMP) promotes cyst enlargement by stimulating cell proliferation and transepithelial fluid secretion. Several interventions affecting many of these defective signaling pathways have been effective in animal models and some are currently being tested in clinical trials. Moreover, the stem cell therapy can improve nephropathies and according to studies were done in this field, can be considered as a hopeful therapeutic approach in future for PKD. This study provides an in\u2010depth review of the relevant molecular pathways associated with the pathogenesis of ADPKD and their implications in development of potential therapeutic strategies.\n                  <\/jats:p>","DOI":"10.1002\/jcp.28094","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T06:10:56Z","timestamp":1547532656000},"page":"12451-12470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Autosomal dominant polycystic kidney disease: Disrupted pathways and potential therapeutic interventions"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-713X","authenticated-orcid":false,"given":"Talieh","family":"Malekshahabi","sequence":"first","affiliation":[{"name":"Department of Stem Cells and Developmental Biology Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloofar","family":"Khoshdel Rad","sequence":"additional","affiliation":[{"name":"Department of Stem Cells and Developmental Biology Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas L.","family":"Serra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Nephrology Klinik Hirslanden Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6933-6344","authenticated-orcid":false,"given":"Reza","family":"Moghadasali","sequence":"additional","affiliation":[{"name":"Department of Stem Cells and Developmental Biology Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"e_1_2_11_1_2_1","doi-asserted-by":"publisher","DOI":"10.5527\/wjn.v4.i4.468"},{"key":"e_1_2_11_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(94)90137\u20106"},{"key":"e_1_2_11_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.246"},{"key":"e_1_2_11_1_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000168725"},{"key":"e_1_2_11_1_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00038.2007"},{"key":"e_1_2_11_1_7_1","doi-asserted-by":"crossref","unstructured":"Ataga K. 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