{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:37:02Z","timestamp":1789900622958,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T00:00:00Z","timestamp":1547251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T00:00:00Z","timestamp":1547251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81170844"],"award-info":[{"award-number":["81170844"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Department of Science and Technology of Hunan Province","doi-asserted-by":"publisher","award":["2014FJ3100"],"award-info":[{"award-number":["2014FJ3100"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Department of Science and Technology of Hunan Province","doi-asserted-by":"publisher","award":["2012ZK3167"],"award-info":[{"award-number":["2012ZK3167"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.18119"],"award-info":[{"award-number":["320.6750.18119"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rhodopsin mutations are associated with the autosomal\u2010dominant form of retinitis pigmentosa (RP). Here we report simultaneous occurrence of RP associated with bilateral nanophthalmos and acute angle\u2010closure glaucoma in patient with a new mutation in rhodopsin (R135W). ARPE\u201019 cells were transfected with myc\u2010tagged wild\u2010type (WT) and R135W rhodopsin constructs. The half\u2010life of WT and R135W rhodopsin was analyzed via cycloheximide chase analysis. We found that R135W rhodopsin was accumulated in the endoplasmic reticulum (ER) and induced unfolded protein response (UPR) and apoptosis. Moreover, chaperone HSP70 alleviated ER stress and prevented apoptosis induced by R135W rhodopsin by attenuating UPR signaling. These findings reveal the novel pathogenic mechanism of RP and suggest that chaperone HSP70 has potential therapeutic significance for RP.<\/jats:p>","DOI":"10.1002\/jcp.28100","type":"journal-article","created":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T04:18:41Z","timestamp":1547266721000},"page":"14100-14108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A new rhodopsin R135W mutation induces endoplasmic reticulum stress and apoptosis in retinal pigment epithelial cells"],"prefix":"10.1002","volume":"234","author":[{"given":"Yixin","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6969-9775","authenticated-orcid":false,"given":"Haibo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangzhou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0470-2467","authenticated-orcid":false,"given":"Haibo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,12]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2188360"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05181.x"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200421136"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.2.151"},{"issue":"10","key":"e_1_2_7_1_6_1","doi-asserted-by":"crossref","first-page":"a017129","DOI":"10.1101\/cshperspect.a017129","article-title":"Genes and mutations causing autosomal dominant retinitis pigmentosa","volume":"5","author":"Daiger S. P.","year":"2014","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-3209-8_16"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911991107"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.04.002"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69740-7"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00186a011"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9235"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2015.145"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2005.02.007"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30485-5"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e06-04-0338"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1443"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2014.2399"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19759"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.28100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.28100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.28100","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.28100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:46:00Z","timestamp":1787125560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.28100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,12]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/jcp.28100"],"URL":"https:\/\/doi.org\/10.1002\/jcp.28100","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,12]]},"assertion":[{"value":"2018-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}