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We investigated the function of miR\u2010375\u20103p in cardiac hypertrophy and its regulating mechanisms. miR\u2010375\u20103p was upregulated in hearts of the transverse aortic constriction rat model and angiotensin II (Ang II)\u2010induced primary cardiomyocyte hypertrophy model; the opposite was observed for lactate dehydrogenase B (LDHB) protein expression. miR\u2010375\u20103p knockdown reduced the surface area of primary cardiomyocytes increased by Ang II treatment and decreased the B\u2010natriuretic peptide (BNP) and \u03b2\u2010myosin heavy chain (\u03b2\u2010MHC) messenger RNA (mRNA) and protein levels. miR\u2010375\u20103p was also observed to directly target LDHB. LDHB knockdown increased the surface area of Ang II\u2010treated primary cardiomyocytes and increased the BNP and \u03b2\u2010MHC mRNA and protein levels. LDHB knockdown attenuated the effects of miR\u2010375\u20103p on the surface area of primary cardiomyocytes and BNP and \u03b2\u2010MHC levels. Therefore, miR\u2010375\u20103p inhibitor suppresses Ang II\u2010induced cardiomyocyte hypertrophy by promoting LDHB expression.<\/jats:p>","DOI":"10.1002\/jcp.28116","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T22:11:59Z","timestamp":1546985519000},"page":"14198-14209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["MicroRNA\u2010375\u20103p inhibitor suppresses angiotensin II\u2010induced cardiomyocyte hypertrophy by promoting lactate dehydrogenase B expression"],"prefix":"10.1002","volume":"234","author":[{"given":"Huijuan","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Zhujiang Hospital of Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Zhujiang Hospital of Southern 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