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Therefore, more attention needs to be paid to finding a medicine to repair these fractures. Amongst the most mysterious herbs,\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    stands out. In the present study, the ameliorating function of\n                    <jats:italic>A. vera<\/jats:italic>\n                    on osteogenesis was studied in vitro and in vivo. Osteoblast\u2010like cells were exposed to\n                    <jats:italic>A. vera<\/jats:italic>\n                    , followed by analysis of cell viability, lactate dehydrogenase release, and intracellular reactive oxygen species (ROS) production. The results showed an enhanced cell biocompatibility in a dose\u2010dependent manner due to attenuated intracellular ROS production. Furthermore, a docking study indicated that the strong affinity of\n                    <jats:italic>A. vera<\/jats:italic>\n                    constituents to type I bone morphogenic protein receptor (BMPR1A) without the involvement of the BMPR1A chain B. The induction of osteogenesis prompts extracellular calcium deposition by osteoblasts, which affirms successful in vitro bone regeneration. However, injection of\n                    <jats:italic>A. vera<\/jats:italic>\n                    in rats with critical size calvarial defects induced Runx2, alkaline phosphatase (ALP), OCN, and BMP2 genes overexpression, which led to the formation of victorious bone with enhanced bone density and ALP activity. It is worthy to note that Aloin has the highest affinity to BMPR1A, whereas there are no reports regarding the impact of Aloenin, Aloesin, and \u03b3\u2010sitosterol on osteogenesis. Furthermore, some of them have antitumor potency, and it might be proposed that they are considered as a bone substitute in the osteotomy site of osteosarcoma with the aim of bone recovery and suppression of osteosarcoma. The whole consequences of this investigation manifests the plausibility of using\n                    <jats:italic>A. vera<\/jats:italic>\n                    as an antioxidant and osteoconductive substitute.\n                  <\/jats:p>","DOI":"10.1002\/jcp.28121","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T23:37:50Z","timestamp":1547768270000},"page":"14246-14258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Strong binding active constituents of phytochemical to BMPR1A promote bone regeneration: In vitro, in silico docking, and in vivo studies"],"prefix":"10.1002","volume":"234","author":[{"given":"Bita","family":"Rasoulian","sequence":"first","affiliation":[{"name":"Cellular and Molecular Research Center Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Almasi","sequence":"additional","affiliation":[{"name":"Department of Medical Nanotechnology Pharmaceutical Sciences Branch Islamic Azad University Pharmaceutical Sciences Branch Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3285-5682","authenticated-orcid":false,"given":"Elham","family":"Hoveizi","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science Shahid Chamran University of Ahvaz Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohre","family":"Bagher","sequence":"additional","affiliation":[{"name":"ENT and Head &amp; Neck Research Center and Department Hazrat Rasoul Akram Hospital Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Hayat","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Taghi","family":"Joghataei","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mahdi","family":"Rezayat","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8531-7650","authenticated-orcid":false,"given":"Shima","family":"Tavakol","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2012.08516.x"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.10.006"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26820-8"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.01.001"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00334492"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1071"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-3948-9"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.4034\/PBOCI.2016.161.11"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1083957"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5631"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477886"},{"issue":"4","key":"e_1_2_7_1_13_1","first-page":"1985","article-title":"Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase\u2010dependent pathway","volume":"40","author":"Dong X.","year":"2018","journal-title":"Oncology Reports"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.13181\/mji.v23i4.1085"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.4.1.1445"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S130514"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.05.002"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2011.01.017"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2010.01151.x"},{"key":"e_1_2_7_1_20_1","unstructured":"2015 RAND Corporation Santa Monica CA B. 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