{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:39:08Z","timestamp":1793126348611,"version":"4.5.0"},"reference-count":186,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cancer incidences are growing and cause millions of deaths worldwide. Cancer therapy is one of the most important challenges in medicine. Improving therapeutic outcomes from cancer therapy is necessary for increasing patients\u2019 survival and quality of life. Adjuvant therapy using various types of antibodies or immunomodulatory agents has suggested modulating tumor response. Resistance to apoptosis is the main reason for radioresistance and chemoresistance of most of the cancers, and also one of the pivotal targets for improving cancer therapy is the modulation of apoptosis signaling pathways. Apoptosis can be induced by intrinsic or extrinsic pathways via stimulation of several targets, such as membrane receptors of tumor necrosis factor\u2010\u03b1 and transforming growth factor\u2010\u03b2, and also mitochondria. Curcumin is a naturally derived agent that induces apoptosis in a variety of different tumor cell lines. Curcumin also activates redox reactions within cells inducing reactive oxygen species (ROS) production that leads to the upregulation of apoptosis receptors on the tumor cell membrane. Curcumin can also upregulate the expression and activity of p53 that inhibits tumor cell proliferation and increases apoptosis. Furthermore, curcumin has a potent inhibitory effect on the activity of NF\u2010\u03baB and COX\u20102, which are involved in the overexpression of antiapoptosis genes such as Bcl\u20102. It can also attenuate the regulation of antiapoptosis PI3K signaling and increase the expression of MAPKs to induce endogenous production of ROS. In this paper, we aimed to review the molecular mechanisms of curcumin\u2010induced apoptosis in cancer cells. This action of curcumin could be applicable for use as an adjuvant in combination with other modalities of cancer therapy including radiotherapy and chemotherapy.<\/jats:p>","DOI":"10.1002\/jcp.28122","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T03:00:30Z","timestamp":1547002830000},"page":"12537-12550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":314,"title":["Mechanisms of apoptosis modulation by curcumin: Implications for cancer therapy"],"prefix":"10.1002","volume":"234","author":[{"given":"Keywan","family":"Mortezaee","sequence":"first","affiliation":[{"name":"Department of Anatomy School of Medicine, Kurdistan University of Medical Sciences Sanandaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ensieh","family":"Salehi","sequence":"additional","affiliation":[{"name":"Department of Anatomy School of Medicine, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanifeh","family":"Mirtavoos\u2010mahyari","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Faculty of Medicine, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elahe","family":"Motevaseli","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine School of Advanced Technologies in Medicine, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Najafi","sequence":"additional","affiliation":[{"name":"Radiology and Nuclear Medicine Department School of Paramedical Sciences, Kermanshah University of Medical Science Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bagher","family":"Farhood","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Radiology Faculty of Paramedical Sciences, Kashan University of Medical Sciences Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda J.","family":"Rosengren","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences Mashhad Iran"},{"name":"School of Pharmacy, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2015.07.022"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.09.006"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25778"},{"issue":"2","key":"e_1_2_8_1_5_1","first-page":"77","article-title":"Medical therapy of prostate cancer: 1999","volume":"96","author":"Afrin L. B.","year":"2000","journal-title":"Journal of the South Carolina Medical Association (1975)"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.06593.x"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(03)00029-7"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210791959818"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467211666180802164449"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(99)00220-X"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.7.4.5534"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.169"},{"issue":"2","key":"e_1_2_8_1_13_1","first-page":"337","article-title":"Increased radiation sensitivity of an eosinophilic cell line following treatment with epigallocatechin\u2010gallate, resveratrol and curcuma","volume":"15","author":"Baatout S.","year":"2005","journal-title":"International Journal of Molecular Medicine"},{"issue":"2","key":"e_1_2_8_1_14_1","first-page":"321","article-title":"Effect of curcuma on radiation\u2010induced apoptosis in human cancer cells","volume":"24","author":"Baatout S.","year":"2004","journal-title":"International Journal of Oncology"},{"key":"e_1_2_8_1_15_1","first-page":"645","article-title":"Protection against radiation\u2010induced micronuclei in rat bone marrow erythrocytes by Curcumin and selenium L\u2010methionine","volume":"43","author":"Bagheri H.","year":"2018","journal-title":"Iranian Journal of Medical Sciences"},{"issue":"3","key":"e_1_2_8_1_16_1","first-page":"277","article-title":"Apoptosis in radiation therapy: A double\u2010edged sword","volume":"34","author":"Balcer\u2010Kubiczek E. K.","year":"2012","journal-title":"Experimental Oncology"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2587"},{"key":"e_1_2_8_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2781"},{"key":"e_1_2_8_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2017.05.001"},{"key":"e_1_2_8_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-7404(97)00015-7"},{"key":"e_1_2_8_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00391-9"},{"key":"e_1_2_8_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401874"},{"issue":"7","key":"e_1_2_8_1_23_1","first-page":"1391","article-title":"Apoptosis, p53, and tumor cell sensitivity to anticancer agents","volume":"59","author":"Brown J. M.","year":"1999","journal-title":"Cancer Research"},{"key":"e_1_2_8_1_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0885"},{"key":"e_1_2_8_1_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.256180"},{"key":"e_1_2_8_1_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2001.5381"},{"key":"e_1_2_8_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(02)01376-7"},{"issue":"2","key":"e_1_2_8_1_28_1","first-page":"436","article-title":"Effect of curcumin on irradiated and estrogen\u2010transformed human breast cell lines","volume":"40","author":"Calaf G. M.","year":"2012","journal-title":"International Journal of Oncology"},{"key":"e_1_2_8_1_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.53"},{"key":"e_1_2_8_1_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.498"},{"key":"e_1_2_8_1_31_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467211666180219102520"},{"issue":"21","key":"e_1_2_8_1_32_1","first-page":"330","article-title":"The critical roles of miR\u201021 in anti\u2010cancer effects of curcumin","volume":"3","author":"Chen J.","year":"2015","journal-title":"Annals of Translational Medicine"},{"issue":"5","key":"e_1_2_8_1_33_1","first-page":"1059","article-title":"Differential roles of RelA (p65) and c\u2010Rel subunits of nuclear factor kappa B in tumor necrosis factor\u2010related apoptosis\u2010inducing ligand signaling","volume":"63","author":"Chen X.","year":"2003","journal-title":"Cancer Research"},{"key":"e_1_2_8_1_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16436-9"},{"key":"e_1_2_8_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.07.1986"},{"key":"e_1_2_8_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02292-5"},{"key":"e_1_2_8_1_37_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2017.69326"},{"key":"e_1_2_8_1_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh233"},{"key":"e_1_2_8_1_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/jrcr.jrcr_32_17"},{"issue":"1","key":"e_1_2_8_1_40_1","first-page":"95","article-title":"Curcumin (diferuloyl\u2010methane) enhances tumor necrosis factor\u2010related apoptosis\u2010inducing ligand\u2010induced apoptosis in lncap prostate cancer cells1","volume":"2","author":"Deeb D.","year":"2003","journal-title":"Molecular Cancer Therapeutics"},{"key":"e_1_2_8_1_41_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.803.3.7"},{"key":"e_1_2_8_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.02.001"},{"key":"e_1_2_8_1_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701320337"},{"key":"e_1_2_8_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2012.10.008"},{"key":"e_1_2_8_1_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-010-0042-8"},{"key":"e_1_2_8_1_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27703"},{"key":"e_1_2_8_1_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27391"},{"key":"e_1_2_8_1_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-018-1934-0"},{"key":"e_1_2_8_1_49_1","article-title":"Disruption of the redox balance with either oxidative or anti\u2010oxidative overloading as a promising target for cancer therapy","author":"Farhood B.","year":"2018","journal-title":"Journal of Cellular Biochemistry"},{"issue":"9","key":"e_1_2_8_1_50_1","first-page":"1164","article-title":"Inhibition of NF\u2010kB enhances chemotherapy induced apoptosis in ovarian cancer cells","volume":"65","author":"Fogoros S.","year":"2005","journal-title":"Cancer Research"},{"key":"e_1_2_8_1_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207116"},{"key":"e_1_2_8_1_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1501292"},{"key":"e_1_2_8_1_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24064"},{"key":"e_1_2_8_1_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209608"},{"key":"e_1_2_8_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.02.008"},{"key":"e_1_2_8_1_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200311000-00001"},{"key":"e_1_2_8_1_57_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666161006151605"},{"issue":"4","key":"e_1_2_8_1_58_1","first-page":"208","article-title":"Enhancement of gamma radiation\u2010induced cytotoxicity of breast cancer cells by curcumin","volume":"1","author":"Girdhani S.","year":"2009","journal-title":"Molecular and Cellular Pharmacology"},{"key":"e_1_2_8_1_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2013.00120"},{"key":"e_1_2_8_1_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00655-3"},{"issue":"14","key":"e_1_2_8_1_61_1","first-page":"10","article-title":"Celecoxib and radiation therapy in non\u2010small\u2010cell lung cancer","volume":"18","author":"Gore E.","year":"2004","journal-title":"Oncology (Williston Park, NY)"},{"key":"e_1_2_8_1_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2011.03.007"},{"key":"e_1_2_8_1_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a011629"},{"key":"e_1_2_8_1_64_1","first-page":"153","article-title":"The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERalpha) in breast cancer cells","volume":"9","author":"Hallman K.","year":"2017","journal-title":"Breast Cancer (Dove Medical Press)"},{"key":"e_1_2_8_1_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs029"},{"key":"e_1_2_8_1_66_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1228704"},{"key":"e_1_2_8_1_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/095530097143716"},{"key":"e_1_2_8_1_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635580903441238"},{"key":"e_1_2_8_1_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh165"},{"key":"e_1_2_8_1_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2010.09.005"},{"key":"e_1_2_8_1_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)01277-4"},{"issue":"1","key":"e_1_2_8_1_72_1","article-title":"Curcumin induces apoptosis by suppressing protein phosphatase 5 leading to activation of JNK cascade","volume":"25","author":"Huang S.","year":"2011","journal-title":"Federation of American Societies for Experimental Biology"},{"key":"e_1_2_8_1_73_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/565316"},{"key":"e_1_2_8_1_74_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.043554"},{"key":"e_1_2_8_1_75_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4258"},{"key":"e_1_2_8_1_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi167"},{"key":"e_1_2_8_1_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgl026"},{"key":"e_1_2_8_1_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4680(00)00053-5"},{"key":"e_1_2_8_1_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2016.10.001"},{"key":"e_1_2_8_1_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04870"},{"key":"e_1_2_8_1_81_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467211666181010154709"},{"key":"e_1_2_8_1_82_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0290"},{"key":"e_1_2_8_1_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16022942"},{"issue":"3","key":"e_1_2_8_1_84_1","first-page":"e2331","article-title":"Anticancer activity of curcumin on human breast adenocarcinoma: Role of Mcl\u20101 gene","volume":"8","author":"Koohpar Z. K.","year":"2015","journal-title":"Iranian Journal of Cancer Prevention"},{"key":"e_1_2_8_1_85_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.51.5.290"},{"key":"e_1_2_8_1_86_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4722"},{"key":"e_1_2_8_1_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24593"},{"key":"e_1_2_8_1_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64681-0"},{"key":"e_1_2_8_1_89_1","doi-asserted-by":"publisher","DOI":"10.5012\/bkcs.2014.35.11.3339"},{"key":"e_1_2_8_1_90_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S96899"},{"issue":"1","key":"e_1_2_8_1_91_1","first-page":"19","article-title":"Apoptotic effects of curcumin via the regulation of COX\u20102\/VASP signaling molecules in MCF\u20107 breast cancer cells","volume":"17","author":"Lee S. H.","year":"2012","journal-title":"Cancer Prevention Research"},{"key":"e_1_2_8_1_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04699.x"},{"key":"e_1_2_8_1_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.11.017"},{"issue":"18","key":"e_1_2_8_1_94_1","first-page":"6738","article-title":"Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells. Clinical cancer research: An official journal of the American Association for","volume":"11","author":"Lev\u2010Ari S.","year":"2005","journal-title":"Cancer Research"},{"key":"e_1_2_8_1_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(05)80045-9"},{"key":"e_1_2_8_1_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei132"},{"issue":"2","key":"e_1_2_8_1_97_1","first-page":"167","article-title":"Targeting transcription factor NF\u2010kappaB to overcome chemoresistance and radioresistance in cancer therapy","volume":"1805","author":"Li F.","year":"2010","journal-title":"Biochimica et Biophysica Acta"},{"key":"e_1_2_8_1_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-015-0168-z"},{"key":"e_1_2_8_1_99_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4319"},{"key":"e_1_2_8_1_100_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.2946"},{"key":"e_1_2_8_1_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5167"},{"key":"e_1_2_8_1_102_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.116.141630"},{"key":"e_1_2_8_1_103_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.5.1626-1638.2000"},{"key":"e_1_2_8_1_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.16.5299-5305.2001"},{"key":"e_1_2_8_1_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00050-9"},{"key":"e_1_2_8_1_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30224"},{"key":"e_1_2_8_1_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26055"},{"key":"e_1_2_8_1_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-007-9056-0"},{"key":"e_1_2_8_1_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/112_2016_3"},{"key":"e_1_2_8_1_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.11.016"},{"key":"e_1_2_8_1_111_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.01171"},{"key":"e_1_2_8_1_112_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh163"},{"key":"e_1_2_8_1_113_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6739"},{"key":"e_1_2_8_1_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi371"},{"key":"e_1_2_8_1_115_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02554"},{"key":"e_1_2_8_1_116_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02579"},{"key":"e_1_2_8_1_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64656-1"},{"key":"e_1_2_8_1_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27646"},{"key":"e_1_2_8_1_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2018.01.007"},{"key":"e_1_2_8_1_120_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553002.2018.1440092"},{"key":"e_1_2_8_1_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1588"},{"key":"e_1_2_8_1_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/364806a0"},{"key":"e_1_2_8_1_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.12.009"},{"key":"e_1_2_8_1_124_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051309"},{"key":"e_1_2_8_1_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5174"},{"key":"e_1_2_8_1_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.12.019"},{"key":"e_1_2_8_1_127_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-100019"},{"key":"e_1_2_8_1_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-016-0301-4"},{"key":"e_1_2_8_1_129_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-101752"},{"key":"e_1_2_8_1_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140815931"},{"key":"e_1_2_8_1_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1752-1"},{"key":"e_1_2_8_1_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.09.012"},{"key":"e_1_2_8_1_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(96)00834-9"},{"key":"e_1_2_8_1_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.3"},{"key":"e_1_2_8_1_135_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.12149FP"},{"key":"e_1_2_8_1_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.451"},{"key":"e_1_2_8_1_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5659"},{"key":"e_1_2_8_1_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00544-1"},{"key":"e_1_2_8_1_139_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211010200"},{"issue":"7","key":"e_1_2_8_1_140_1","first-page":"2567","article-title":"Death by design: Where curcumin sensitizes drug\u2010resistant tumours","volume":"32","author":"Saha S.","year":"2012","journal-title":"Anticancer Research"},{"key":"e_1_2_8_1_141_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnv024"},{"key":"e_1_2_8_1_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.01.005"},{"key":"e_1_2_8_1_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.03.026"},{"key":"e_1_2_8_1_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.04.007"},{"key":"e_1_2_8_1_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-011-1008-4"},{"key":"e_1_2_8_1_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-001-0479-6"},{"key":"e_1_2_8_1_147_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057218"},{"key":"e_1_2_8_1_148_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1291-0"},{"issue":"4","key":"e_1_2_8_1_149_1","first-page":"905","article-title":"Involvement of Bcl\u20102 family members, phosphatidylinositol 3'\u2010kinase\/AKT and mitochondrial p53 in curcumin (diferulolylmethane)\u2010induced apoptosis in prostate cancer","volume":"30","author":"Shankar S.","year":"2007","journal-title":"International Journal of Oncology"},{"key":"e_1_2_8_1_150_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-7-16"},{"key":"e_1_2_8_1_151_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-2187-2-10"},{"key":"e_1_2_8_1_152_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_8_1_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.54"},{"key":"e_1_2_8_1_154_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.2.281"},{"issue":"13","key":"e_1_2_8_1_155_1","first-page":"3868","article-title":"Dietary curcumin inhibits chemotherapy\u2010induced apoptosis in models of human breast cancer","volume":"62","author":"Somasundaram S.","year":"2002","journal-title":"Cancer Research"},{"key":"e_1_2_8_1_156_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6199"},{"issue":"7","key":"e_1_2_8_1_157_1","first-page":"597","article-title":"Apoptosis in the genesis and prevention of cancer. Cancer epidemiology, biomarkers & prevention: A publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive","volume":"1","author":"Thompson H. J.","year":"1992","journal-title":"Oncology"},{"key":"e_1_2_8_1_158_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gms074"},{"issue":"1","key":"e_1_2_8_1_159_1","first-page":"232","article-title":"Comparison of the effect of p65 siRNA and curcumin in promoting apoptosis in esophageal squamous cell carcinoma cells and in nude mice","volume":"28","author":"Tian F.","year":"2012","journal-title":"Oncology Reports"},{"key":"e_1_2_8_1_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.07.027"},{"key":"e_1_2_8_1_161_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2017.0049"},{"key":"e_1_2_8_1_162_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13701"},{"key":"e_1_2_8_1_163_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.3.1007-1021.2004"},{"key":"e_1_2_8_1_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-419X(99)00032-3"},{"key":"e_1_2_8_1_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.10.050"},{"key":"e_1_2_8_1_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207232"},{"key":"e_1_2_8_1_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.01.013"},{"key":"e_1_2_8_1_168_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6053"},{"key":"e_1_2_8_1_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08566"},{"key":"e_1_2_8_1_170_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-017-0979-x"},{"issue":"6","key":"e_1_2_8_1_171_1","first-page":"2125","article-title":"Curcumin induces apoptosis in human non\u2010small cell lung cancer NCI\u2010H460 cells through ER stress and caspase cascade\u2010 and mitochondria\u2010dependent pathways","volume":"30","author":"Wu S.\u2010H.","year":"2010","journal-title":"Anticancer Research"},{"key":"e_1_2_8_1_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.128"},{"key":"e_1_2_8_1_173_1","doi-asserted-by":"publisher","DOI":"10.31661\/jbpe.v0i0.713"},{"issue":"3","key":"e_1_2_8_1_174_1","first-page":"0","article-title":"Metformin protects against radiation\u2010induced heart injury and attenuates the up\u2010regulation of dual oxidase genes following rat's chest irradiation","volume":"7","author":"Yahyapour R.","year":"2018","journal-title":"International Journal of Molecular and Cellular Medicine"},{"key":"e_1_2_8_1_175_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467211666180619125653"},{"key":"e_1_2_8_1_176_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-2215-3-11"},{"key":"e_1_2_8_1_177_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-12-22"},{"key":"e_1_2_8_1_178_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2017.1384863"},{"issue":"11","key":"e_1_2_8_1_179_1","first-page":"2342","article-title":"Protective effect of curcumin on chemotherapy\u2010induced intestinal dysfunction","volume":"6","author":"Yao Q.","year":"2013","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_8_1_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.10.008"},{"key":"e_1_2_8_1_181_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666161010115235"},{"key":"e_1_2_8_1_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.136"},{"key":"e_1_2_8_1_183_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/20.3.445"},{"key":"e_1_2_8_1_184_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574362410666150109223303"},{"key":"e_1_2_8_1_185_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101121"},{"key":"e_1_2_8_1_186_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-013-1135-9"},{"key":"e_1_2_8_1_187_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5787218"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.28122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.28122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.28122","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.28122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:44:21Z","timestamp":1787125461000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.28122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,8]]},"references-count":186,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/jcp.28122"],"URL":"https:\/\/doi.org\/10.1002\/jcp.28122","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,8]]},"assertion":[{"value":"2018-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}