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The therapeutic methods for this malignancy are not effective, and due to the side effects of these treatments, applying an appropriate alternative or complementary treatment is important. According to available data, melatonin as the main product of the pineal gland has oncostatic and antitumoral properties. Also, melatonin acts as an anti\u2010inflammatory and reactive oxygen species inducer agent which suppresses the growth of tumors. It also has apoptosis induction characteristics through regulating signaling pathways, including heat shock protein 70, nuclear factor\u2010erythroid 2 p45\u2010related factor 2 and others. Thus, adding melatonin to chemo\u2010 and radiotherapy may have synergistic therapeutic effects and increase the survival time in patients with skin cancer. Few clinical studies have evaluated the efficacy of melatonin in skin cancer. Based on the related mechanisms, this review discusses about how melatonin may improve outcomes in skin cancer patients.<\/jats:p>","DOI":"10.1002\/jcp.28129","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T22:11:26Z","timestamp":1546985486000},"page":"12142-12148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Potential use of melatonin in skin cancer treatment: A review of current biological evidence"],"prefix":"10.1002","volume":"234","author":[{"given":"Mohammad Hossein","family":"Pourhanifeh","sequence":"first","affiliation":[{"name":"Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences Kashan I. R. 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