{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T08:25:38Z","timestamp":1787127938830,"version":"build-2736575974"},"reference-count":217,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T00:00:00Z","timestamp":1547337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T00:00:00Z","timestamp":1547337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Elevated plasma lipoprotein(a) (Lp(a)) levels are associated with an increased risk of cardiovascular disease (CVD). Hitherto, niacin has been the drug of choice to reduce elevated Lp(a) levels in hyperlipidemic patients but its efficacy in reducing CVD outcomes has been seriously questioned by recent clinical trials. Additional drugs may reduce to some extent plasma Lp(a) levels but the lack of a specific therapeutic indication for Lp(a)\u2010lowering limits profoundly reduce their use. An attractive therapeutic option is natural products. In several preclinical and clinical studies as well as meta\u2010analyses, natural products, including\n                    <jats:sc>l<\/jats:sc>\n                    \u2010carnitine, coenzyme Q\n                    <jats:sub>10<\/jats:sub>\n                    , and xuezhikang were shown to significantly decrease Lp(a) levels in patients with Lp(a) hyperlipoproteinemia. Other natural products, such as pectin,\n                    <jats:italic>Ginkgo biloba<\/jats:italic>\n                    , flaxseed, red wine, resveratrol and curcuminoids can also reduce elevated Lp(a) concentrations but to a lesser degree. In conclusion, aforementioned natural products may represent promising therapeutic agents for Lp(a) lowering.\n                  <\/jats:p>","DOI":"10.1002\/jcp.28134","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T00:05:23Z","timestamp":1547424323000},"page":"12581-12594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Dietary natural products as emerging lipoprotein(a)\u2010lowering agents"],"prefix":"10.1002","volume":"234","author":[{"given":"Amir Abbas","family":"Momtazi\u2010Borojeni","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnology Nanotechnology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0894-2644","authenticated-orcid":false,"given":"Niki","family":"Katsiki","sequence":"additional","affiliation":[{"name":"Second Propedeutic Department of Internal Medicine, Medical School Aristotle University of Thessaloniki, Hippocration Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5527-4821","authenticated-orcid":false,"given":"Matteo","family":"Pirro","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Banach","sequence":"additional","affiliation":[{"name":"Department of Hypertension WAM University Hospital in Lodz, Medical University of Lodz Lodz Poland"},{"name":"Polish Mother's Memorial Hospital Research Institute Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid Al","family":"Rasadi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Sultan Qaboos University Hospital Muscat Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences Mashhad Iran"},{"name":"School of Pharmacy, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,13]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666160527113501"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25778"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(75)80015-1"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(82)90305-5"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.15.1765"},{"key":"e_1_2_8_1_7_1","first-page":"55G","article-title":"Dietary fibre, complex carbohydrate and coronary artery disease","volume":"11","author":"Anderson J. 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