{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:16:33Z","timestamp":1782890193602,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T00:00:00Z","timestamp":1548460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The adrenal gland is an important endocrine gland in the body that secrets the adrenal hormones. One of the important clinical issues is the hepatic ischemia\u2013reperfusion (IR) injury. Liver IR injury results in many distant organs dysfunctions such as lung, kidney, intestine, pancreas, and myocardium. The aim of the present study was to investigate the possible remote effects of hepatic IR on the structure of the adrenal cortex. Twenty healthy males, Sprague\u2013Dawley albino rats aged 6\u20138 weeks were randomly divided into two groups (10 rats each): the sham control group (SC\u2010group) and the ischemia\u2013reperfusion group (IR\u2010group). Sera were estimated for the following: aspartate transaminase (AST), alanine transaminase (ALT), lactic dehydrogenase (LDH), and corticosterone levels. Also oxidative markers such as malondialdehyde (MDA) and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), and the antioxidative enzyme, catalase were measured. Adrenal glands were processed for light and transmission electron microscopic study. The results showed a significant increase in serum liver enzymes (AST, ALT, and LDH), corticosterone, MDA, and TNF\u2010\u03b1 levels and a significant decrease in serum levels of catalase in IR\u2010group compared with SC\u2010group. Adrenal cortical tissue of IR\u2010group showed the loss of normal appearance. Some cells of zona glomerulosa and most of the zona fasciculata cells appeared swollen and degenerated with highly vacuolated cytoplasm. Other cells were shrunken with deeply acidophilic cytoplasm and pyknotic nuclei. Degenerated mitochondria with disrupted cristae, lipid droplets were confluent and dilated smooth endoplasmic reticulum were seen. Few zona reticularis cells had the dark nucleus and cytoplasmic vacuolations. In the different zones, blood capillaries were markedly congested and some inflammatory cells infiltrations were observed. Liver IR affected the structure of the adrenal cortex.<\/jats:p>","DOI":"10.1002\/jcp.28196","type":"journal-article","created":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T08:56:41Z","timestamp":1548493001000},"page":"15487-15495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The possible structural changes in the adrenal gland cortex after induction of hepatic ischemia\u2013reperfusion injury in male albino rats: Light and electron microscopic study"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2660-9909","authenticated-orcid":false,"given":"Nashwa Fathy Gamal","family":"El\u2010Tahawy","sequence":"first","affiliation":[{"name":"Department of Histology and Cell Biology Faculty of Medicine, Minia University Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4142-2344","authenticated-orcid":false,"given":"Samah Mohammed Mahmoud","family":"Abozaid","sequence":"additional","affiliation":[{"name":"Department of Anatomy Faculty of Medicine, Minia University Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,26]]},"reference":[{"key":"e_1_2_9_1_2_1","first-page":"112","article-title":"Hypolipidemic influence of Sargassum subrepandum: Mechanism of action","volume":"16","author":"Ahmed H. 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