{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T11:47:00Z","timestamp":1769082420564,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T00:00:00Z","timestamp":1550534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["941684"],"award-info":[{"award-number":["941684"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High\u2010density lipoprotein (HDL) function rather than level may better predict cardiovascular disease (CVD). However, the contribution of the impaired antioxidant function of HDL that is associated with increased HDL lipid peroxidation (HDLox) to the development of clinical CVD remains unclear. We have investigated the association between serum HDLox with incident CVD outcomes in Mashhad cohort. Three\u2010hundred and\u00a0thirty individuals who had a median follow\u2010up period of 7\u2009years were recruited as part of the cohort. The primary end point was cardiovascular event, including myocardial infarction, stable angina, unstable angina, or coronary revascularization. In both univariate\/multivariate analyses adjusted for traditional CVD risk factors, HDLox was an independent risk factor for CVD (odds ratio, 1.62; 95% confidence interval, 1.41\u20131.86; \n<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). For every increase in HDLox by 0.1 unit, there was an increase in CVD risk by 1.62\u2010fold. In an adjusted analysis, there was a &gt;2.5\u2010fold increase in cardiovascular risk in individuals with HDLox higher than cutoff point of 1.06 compared to those with lower scores, suggesting HDLox\u2009&gt;\u20091.06 is related to the impaired HDL oxidant function and in turn exposed to elevated risk of CVD outcomes (hazard ratio, 2.72; 95% CI, 1.88\u20133.94). Higher\u00a0HDLox is a surrogate measure of reduced HDL antioxidant function that positively associated with cardiovascular events in a population\u2010based cohort.<\/jats:p>","DOI":"10.1002\/jcp.28276","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T04:05:32Z","timestamp":1550635532000},"page":"16168-16177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["High\u2010density lipoprotein lipid peroxidation as a molecular signature of the risk for developing cardiovascular disease: Results from MASHAD cohort"],"prefix":"10.1002","volume":"234","author":[{"given":"Sara","family":"Samadi","sequence":"first","affiliation":[{"name":"Department of Modern Sciences and Technologies, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Student Research Committee, Faculty of Medicine Mashhad University of Medical Sciences Mashhad 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Hosein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habibollah","family":"Esmaily","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Moohebati","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Farjami","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon 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