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Slc4a7 was immunolocalized to the apical membrane of mouse submandibular duct cells. In contrast, Slc4a7 was not detected in acinar cells, and correspondingly, \n<jats:italic>Slc4a7<\/jats:italic> disruption did not affect fluid secretion in response to cholinergic or \u03b2\u2010adrenergic stimulation in the submandibular gland (SMG). Much of the Na\n<jats:sup>+<\/jats:sup>\u2010dependent intracellular pH (pH\n<jats:sub>i<\/jats:sub>) regulation in SMG duct cells was insensitive to 4,4\u2032\u2010diisothiocyano\u20102,2\u2032\u2010stilbenedisulfonic acid, S0859, and to the removal of extracellular HCO\n<jats:sub>3<\/jats:sub>\n<jats:sup>\u2212<\/jats:sup>. Consistent with these latter observations, the \n<jats:italic>Slc4a7<\/jats:italic> null mutation had no impact on HCO\n<jats:sub>3<\/jats:sub>\n<jats:sup>\u2212<\/jats:sup> secretion nor on pH\n<jats:sub>i<\/jats:sub> regulation in duct cells. Taken together, our results revealed that Slc4a7 targets to the apical membrane of mouse SMG duct cells where it contributes little if any to pH\n<jats:sub>i<\/jats:sub> regulation or stimulated HCO\n<jats:sub>3<\/jats:sub>\n<jats:sup>\u2212<\/jats:sup> secretion.<\/jats:p>","DOI":"10.1002\/jcp.28306","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T04:46:51Z","timestamp":1550206011000},"page":"16376-16388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The apical Na<sup>+<\/sup>\u2013HCO<sub>3<\/sub><sup>\u2212<\/sup> cotransporter Slc4a7 (NBCn1) does not contribute to bicarbonate transport by mouse salivary gland ducts"],"prefix":"10.1002","volume":"234","author":[{"given":"Ning\u2010Yan","family":"Yang","sequence":"first","affiliation":[{"name":"Secretory Mechanisms and Dysfunctions Section National Institute of Dental and Craniofacial Research National Institutes of Health 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