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Forkhead box protein 3 (<jats:italic>FOXP3<\/jats:italic>) is the key transcription factor of Treg. We performed a systematic review and meta\u2010analysis to evaluate the possible association between <jats:italic>FOXP3<\/jats:italic> polymorphisms \u2212924A\/G (rs2232365) and \u22123279C\/A (rs3761548) and immune\u2010related pregnancy complications. After reviewing 78 fully published studies, 10 studies fulfilled previously defined eligibility criteria and were used for meta\u2010analysis. Two single nucleotide polymorphisms showed a significant correlation with increased or reduced risk for immune\u2010related pregnancy complications. For rs3761548, women with allele A were significantly at a higher risk than women carrying allele C (odds ratio\u2009=\u20091.29, 95% confidence interval: 1.20\u20131.38; <jats:italic>p<\/jats:italic>\u2009=\u20090.001). For rs2232365, women with GG or AG genotype were at a higher risk than women with genotype AA, thereby, allele G was significantly associated with a higher risk than allele A. Our meta\u2010analysis supports the notion that immune\u2010related pregnancy complications might be linked to genetic variations in the FOXP3 gene.<\/jats:p>","DOI":"10.1002\/jcp.28328","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T04:06:25Z","timestamp":1550635585000},"page":"16573-16581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Influence of forkhead box protein 3 polymorphisms (rs2232365, rs3761548) with the outcome of pregnancy: A meta\u2010analysis"],"prefix":"10.1002","volume":"234","author":[{"given":"Saeed","family":"Hosseini Teshnizi","sequence":"first","affiliation":[{"name":"Department of Biostatistics Fertility and Infertility Research Center, Hormozgan University of Medical Sciences Bandar Abbas Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Ali\u2010Hassanzadeh","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine, Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Department of Immunology School of Medicine, Jiroft University of Medical Sciences Jiroft Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0162-3395","authenticated-orcid":false,"given":"Behrouz","family":"Gharesi\u2010Fard","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine, Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Infertility Research Center, Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Kabelitz","sequence":"additional","affiliation":[{"name":"Institute of immunology, University of Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9160-9449","authenticated-orcid":false,"given":"Kurosh","family":"Kalantar","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine, Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,19]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"crossref","unstructured":"K. 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