{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:34:03Z","timestamp":1788809643929,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["182300410369"],"award-info":[{"award-number":["182300410369"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We hypothesized that the adipose\u2010derived mesenchymal stem cells (ADMSCs), which secrete high amounts of soluble molecules, such as soluble tumor necrosis factor receptor 1 (sTNFR1), may ameliorate sepsis\u2010induced acute lung injury (ALI). A total of 120 male adult Sprague\u2013Dawley rats were separated into four groups: the sham control (SC), sepsis induced by cecal ligation and puncture (CLP), CLP\u2013ADMSCs, and CLP\u2013sTNFR1 small interfering RNA (siRNA) groups; CLP groups underwent CLP and then received 1\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> ADMSCs with or without knockdown of sTNFR1 intravenously at 1\u2009hr after surgery. Rats were killed at 3, 6, 24, and 48\u2009hr after the SC or CLP procedures. 5\u2010Ethynyl\u20102\u2032\u2010deoxyuridine\u2010labeled ADMSCs extensively colonized the lungs at 6, 24, and 72\u2009hr after injection. The lung wet\/dry (W\/D) weight ratios in the CLP group were higher than those in SC group; however, ADMSCs ameliorated the W\/D weight ratios following CLP, and this effect was abolished by sTNFR1 siRNA treatment. The levels of serum sTNFR1 and interleukin\u201010 (IL\u201010) were higher in the CLP\u2013ADMSCs group and lower in the SC group than in other groups; interestingly, these levels were higher in CLP and CLP\u2013sTNFR1 siRNA groups than in SC group. Tumor necrosis factor\u2010\u03b1 and IL\u20106 levels increased significantly after CLP, and ADMSCs could alleviate these changes, but the effect was weakened by sTNFR1 siRNA treatment. The lung cell apoptosis and edema levels were consistent with IL\u20106 levels among all groups. Therapeutically administered ADMSCs secrete sTNFR1, which most likely protects against ALI in septic rats by ameliorating inflammation and lung edema.<\/jats:p>","DOI":"10.1002\/jcp.28329","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T04:08:44Z","timestamp":1550549324000},"page":"16582-16591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["RETRACTED: Adipose\u2010derived mesenchymal stem cells ameliorate the inflammatory reaction in CLP\u2010induced septic acute lung injury rats via sTNFR1"],"prefix":"10.1002","volume":"234","author":[{"given":"Xian\u2010Fei","family":"Ding","sequence":"first","affiliation":[{"name":"Department of General ICU The First Affiliated Hospital of Zhengzhou University Henan Key Laboratory of Critical Care Medicine Zhengzhou China"},{"name":"Academy of Medical Sciences of Zhengzhou University Translational Medicine platform Zhengzhou 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