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It is characterized by dysregulated adipokine\u00a0secretion, which contributes to insulin resistance of key metabolic tissues, including the liver, skeletal muscles, and fat itself. The inter\u2010organ cross talk between the adipose tissue and the other organs\u00a0as well as the intra\u2010organ cross talk between adipocytes and macrophages within the adipose tissue, traditionally mediated by hormones, was recently evidenced to be regulated by adipose\u2010derived exosomes. Exosomes are nano\u2010sized membrane\u2010bound vesicles secreted by the donor cells to modify intercellular communication by translating constituent nucleic acids and proteins to the target cells. Herein, we reviewed the latest progress in understanding the role of adipose\u2010derived exosomes in the development of insulin resistance, a key mechanism that underpins diabetes and diabetic complications,\u00a0with a special focus on the role of exosomal miRNAs (micro RNAs) and proteins,\u00a0and discusses the potential implications of targeting adipose tissue\u2010derived exosomes for diabetic therapeutics.<\/jats:p>","DOI":"10.1002\/jcp.28354","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T14:04:48Z","timestamp":1551189888000},"page":"16692-16702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Adipose\u2010derived exosomes: A novel adipokine in obesity\u2010associated 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