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Identification of natural compounds that can suppress osteoclast formation and function is crucial for the prevention and treatment of osteolytic diseases. Vitexin, a naturally\u2010derived flavonoid extracted from various medicinal plant species, demonstrates a broad range of pharmacological properties including anticancer and anti\u2010inflammatory effects. Here in this study, we showed that vitexin exerts antiosteoclastogenic effects by directly inhibiting receptor activator of nuclear factor\u2010\u03baB ligand (RANKL)\u2010induced osteoclast formation and bone resorption in vitro and protected against lipopolysaccharide (LPS)\u2010induced inflammatory osteolysis in vivo. Vitexin suppressed the early activation of ERK and p38 MAPK pathways in response to RANKL thereby attenuating the downstream induction of c\u2010Fos and NFATc1, and abrogating the expression of osteoclast marker genes. Collectively, these results provide evidence for the therapeutic application of vitexin in the treatment of osteoclast\u2010mediated bone lytic diseases.<\/jats:p>","DOI":"10.1002\/jcp.28378","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:15:08Z","timestamp":1550794508000},"page":"17549-17560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Vitexin suppresses RANKL\u2010induced osteoclastogenesis and prevents lipopolysaccharide (LPS)\u2010induced osteolysis"],"prefix":"10.1002","volume":"234","author":[{"given":"Jiawei","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Shaoxing Hospital Zhejiang University School of Medicine Shaoxing Zhejiang China"},{"name":"Department of Orthopaedics Shaoxing People's Hospital Shaoxing Zhejiang China"},{"name":"Department of Orthopaedics Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 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